Results 71 to 80 of about 3,876 (171)
Veterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka +3 more
wiley +1 more source
An In Vivo Study of the Mammalian Mitotic Kinesin Eg5
During mitosis, replicated chromosomes are equally distributed among two daughter cells by means of a multi-component machine called the mitotic spindle.
Gable, Alyssa D
core +1 more source
Investigation of the Mechanochemical Cycle of the Mitotic Kinesin Eg5 [PDF]
, 2006 Cytoskeletal motor proteins utilize the energy from ATP turnover to perform work along their filament tracks. Eg5 is a microtubule-based motor of the Kinesin-5/BimC family that is essential for bipolar spindle formation during eukaryotic cell division. I
Cochran, Jared Clinton
core
Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes [PDF]
, 2019 Arry-520 is an advanced drug candidate from the Eg5 inhibitor class undergoing clinical evaluation in patients with relapsed or refractory multiple myeloma. Here we show by structural analysis that Arry-520 binds stoichiometrically to the motor domain of
Indorato, R-L +6 more
core +3 more sources
Journal of Saudi Chemical Society, 2019 The versatility of multicomponent Biginelli’s reaction is exploited in the development of proline and cyclized cysteine tethered conjugates of monastrol, a kinesin Eg5 inhibitor.
M. Shaheer Malik +8 more
doaj +1 more source
Cell Reports, 2020 Summary: Centrosome separation in late G2/ early prophase requires precise spatial coordination that is determined by a balance of forces promoting and antagonizing separation. The major effector of centrosome separation is the kinesin Eg5.
Tom Stiff +5 more
doaj +1 more source
Corporate Social Responsibility and Environmental Management, Volume 33, Issue 1, Page 321-344, January 2026.ABSTRACT This study seeks to identify and analyze the major factors that contribute to an inclusive workforce for women in the area of logistics and supply chain. It further addresses the need for gender diversity and inclusivity in a traditionally male‐dominated field by adopting a human‐centric approach.
Vernika Agarwal +4 more
wiley +1 more source
Aurora A, MCAK, and Kif18b promote Eg5-independent spindle formation [PDF]
, 2017 Inhibition of the microtubule (MT) motor protein Eg5 results in a mitotic arrest due to the formation of monopolar spindles, making Eg5 an attractive target for anti-cancer therapies. However, Eg5-independent pathways for bipolar spindle formation exist,
Halim, Vincentius A +8 more
core
Deciphering protein function during mitosis in PtK cells using RNAi
BMC Cell Biology, 2006 Background Studying mitosis requires a system in which the dramatic movements of chromosomes and spindle microtubules can be visualized. PtK cells, due to their flat morphology and their small number of large chromosomes, allow microscopic visualizations
Kline Susan L +3 more
doaj +1 more source
Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.
, 2018 The microtubule-dependent kinesin-like protein Eg5 from Homo sapiens is involved in the assembly of the mitotic spindle. It shows a three-domain structure with an N-terminal motor domain, a central coiled coil, and a C-terminal tail domain. In vivo HsEg5
Dimitrios A Skoufias (5065409) +11 more
core +1 more source