Results 91 to 100 of about 3,876 (171)

Comparative Analysis of Loxoprofen Loaded Ethosomal Gel Formulations Incorporating Carbopol and Hydroxypropyl Methylcellulose

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Transdermal delivery is recognized as one of  the most advantageous non-invasive drug  delivery technologies; but the skin's natural  barrier, particularly the stratum corneum,  restricts drug permeation.
Sarah Jabbar Abd Alhur, Hasanain Shakir Mahmood, Pegah Khosravian Dehkordi   +2 more
doaj   +1 more source

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement

Molecules, 2019
S-trityl-l-cysteine (STLC) is a well-recognized lead compound known for its anticancer activity owing to its potent inhibitory effect on human mitotic kinesin Eg5.
Mohamed O. Radwan, Halil I. Ciftci, Taha F. S. Ali, Doha E. Ellakwa, Ryoko Koga, Hiroshi Tateishi, Akiko Nakata, Akihiro Ito, Minoru Yoshida, Yoshinari Okamoto, Mikako Fujita, Masami Otsuka   +11 more
doaj   +1 more source

Eg5 and TPX2 in cohesion fatigue

, 2015
The fidelity of chromosome segregation is ensured by organized cleavage of cohesin at the metaphase-to-anaphase transition. However, prolonged metaphase arrest by proteasomal inhibitor MG132 resulted in an asynchronous loss of sister chromatid cohesion ...
Yeap, Szu Ling
core  

Valorization of waste forest biomass toward the production of cello-oligosaccharides with potential prebiotic activity by utilizing customized enzyme cocktails

Biotechnology for Biofuels, 2019
Background Production of value-added materials from lignocellulosic biomass residues is an emerging sector that has attracted much attention as it offers numerous benefits from an environmental and economical point of view.
Anthi Karnaouri, Leonidas Matsakas, Eleni Krikigianni, Ulrika Rova, Paul Christakopoulos   +4 more
doaj   +1 more source

Cytotoxic monastrol derivatives as adjective inhibitors of drug-resistant Eg5: a molecular dynamics perspective

The mitotic kinesin Eg5 is a motor protein involved in the formation of bipolar spindle and cell division. Eg5 is overexpressed in various cancer cells and Eg5 targeting agents are promising candidates for cancer therapy.
N. Razzaghi-Asl (18119229), S. Shahabipour (18119223), A. N. Shamkhali (18119226)   +2 more
core   +1 more source

Load-dependent release limits the processive stepping of the tetrameric Eg5 motor

, 2007
Tetrameric motor proteins of the Kinesin-5 family are essential for eukaryotic cell division. The microscopic mechanism by which Eg5, the vertebrate Kinesin-5, drives bipolar mitotic spindle formation remains unknown.
Schmidt, C., Stefan Lakämper, Korneev, Mikhail J., Mikhail J. Korneev, Lakamper, S., Lakämper, Stefan, Christoph F. Schmidt, Schmidt, Christoph, Korneev, M.   +8 more
core   +1 more source

Investigating the Biochemical Interaction between Eg5 and TPX2 and Its Role in Branching Microtubule Nucleation

, 2023
Cell division is a critical process for the development of cellular organisms. During cell division, a bipolar structure termed the mitotic spindle must be built from microtubule filaments to align and segregate chromosomes.
Tran, Haley
core  

Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity

, 2017
To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 “braking” dominates motility.
Geng-Yuan Chen (3772138), A. Sophia Gayek (2826323), Erkan Tüzel (3772144), Ryoma Ohi (1340376), Wiphu Youyen (3772135), William O. Hancock (360039), You Jung Kang (3772141)   +6 more
core   +1 more source

The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

, 2019
Nek6 and Nercc1 (also known as Nek9) belong to the NIMA family of protein kinases. Nercc1 is activated in mitosis, whereupon it binds, phosphorylates and activates Nek6.
Regué, Laura, Caelles, Carme, Groen, Aaron, Nicolàs, Marta, Bertran, M. Teresa, Roig, Joan, Rapley, Joseph, Avruch, Joseph   +7 more
core   +1 more source

Receptor–ligand interaction-based virtual screening for novel Eg5/Kinesin spindle protein inhibitors

, 2012
Eg5/KSP is a promising mitotic spindle target for drug discovery in cancer chemotherapy and the development of agents against fungal diseases. A range of Eg5 targeting compounds identified by in vitro or cell-based screening is currently in development ...
Pae, A.N., Nagarajan, S., Kozielski, F., Skoufias, D.A.   +3 more
core   +1 more source