Results 81 to 90 of about 3,876 (171)
Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
, 2009 SummaryBackgroundThe formation of a bipolar spindle is an essential step during cell division. Bipolar spindle assembly is driven by the highly conserved microtubule motor Eg5 (kinesin-5), which can slide antiparallel microtubules apart to drive ...
René H. Medema +11 more
core +1 more source
Design and synthesis of novel EG5 inhibitors
, 2010 The currently available antimitotic drugs directly target the microtubule building blocks. These drugs induce adverse side-effects including neurotoxicity, and cancer cells can potentially develop resistance to them.
Sutcliffe, O. B. +5 more
core +1 more source
Discover ChemistryCancer has emerged as a rapidly escalating global health challenge in the modern world. According to World Health Organization estimates from 2022, cancer affects approximately one in six individuals and remains a leading cause of mortality worldwide ...
Anandsing F. Patil +6 more
doaj +1 more source
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
Nature Communications, 2016 One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.
Jinxue He +8 more
doaj +1 more source
Cell Reports, 2014 The Anaphase-promoting complex/cyclosome (APC/C) cofactor Cdh1 modulates cell proliferation by targeting multiple cell-cycle regulators for ubiquitin-dependent degradation.
Manuel Eguren +10 more
doaj +1 more source
Cancer drug therapy and stochastic modeling of “nano-motors”
International Journal of Nanomedicine, 2018 Lubna Sherin,1 Shabieh Farwa,2 Ayesha Sohail,3 Zhiwu Li,4,5 O Anwar Bég6 1Department of Chemistry, COMSATS University Islamabad, Lahore 54000, Pakistan; 2Department of Mathematics, COMSATS University Islamabad, Wah Cantt, Pakistan; 3Department of
Sherin L +4 more
doaj
Evidence that Monastrol Is an Allosteric Inhibitor of the Mitotic Kinesin Eg5
, 2002 Monastrol, a cell-permeable inhibitor of the kinesin Eg5, has been used to probe the dynamic organization of the mitotic spindle. The mechanism by which monastrol inhibits Eg5 function is unknown.
Maliga, Zoltan +2 more
core +1 more source
The Quest for Ligands Against Kinesin Motor Protein Eg5
The Kinesin Eg5 motor protein is essential for the formation of the mitotic spindles and chromosome segregation, which is necessary for cell division. The inhibition of Eg5 has emerged as a potential therapeutic strategy for inhibiting the uncontrolled ...
Carradori S. +4 more
core +1 more source
, 2011 Time series of confocal fluorescence microscopy images of Eg5-paGFP (green) and Cy5 microtubules (MT; red) at the indicated times, and fluorescence intensity profiles () for Cy5 microtubules and Eg5-paGFP of the same spindle at the indicated times.
Marianne Uteng (53549) +4 more
core +1 more source
Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness [PDF]
, 2014 Novel biomarkers predicting prostate cancer (PCa) aggressiveness and docetaxel therapy response of PCa patients are needed. In this study the correlation between nuclear Eg5-expression, PCa docetaxel response and PCa aggressiveness was assessed ...
Smit, V.T.H.B.M. (Vincent) +8 more
core +1 more source