Results 101 to 110 of about 3,876 (171)

Eg5 Overexpression Is Predictive of Poor Prognosis in Hepatocellular Carcinoma Patients

, 2017
Eg5 (kinesin spindle protein) plays an essential role in mitosis. Inhibition of Eg5 function results in cell cycle arrest at mitosis, which leads to cell death.
Jieying Li, Jun Kong, Nan Zhou, Xudong Wang, Xi Guan, Can Liu   +5 more
core   +1 more source

Dynein Antagonizes Eg5 by Crosslinking and Sliding Antiparallel Microtubules

, 2009
SummaryMitotic spindle assembly requires the combined activity of various molecular motor proteins, including Eg5 [1] and dynein [2]. Together, these motors generate antagonistic forces during mammalian bipolar spindle assembly [3]; what remains unknown,
Wadsworth, Patricia, Mogilner, Alex, Fagerstrom, C, Ferenz, NP, Mogilner, A, Paul, Raja, Wadsworth, P, Ferenz, Nick P., Fagerstrom, Carey, Paul, R   +9 more
core   +1 more source

Suporting Video Legends from Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes

, 2019
SV1-SV6: Time lapse imaging of untreated, Arry-520 and ispinesib treated naive U2OS cells, Eg5(D130) and Eg5(L214) expressing U2OS cells followed for 16h.
Frank Kozielski (1283658), Simon P. Mackay (372724), Shozeb Haider (15075967), Dimitrios A. Skoufias (173868), Fangzhu Lin (15075964), Rose-Laure Indorato (2449525), Sandeep K. Talapatra (1920820)   +6 more
core   +1 more source

The discovery and development of Eg5 inhibitors for the clinic

, 2015
The mitotic kinesin Eg5 (also known as kinesin spindle protein, KSP, Kif11, a member of the kinesin-5 family) represents an attractive oncology drug target in the ongoing development of anti-mitotic drugs that selectively block mitosis through disruption
Berretta, Giacomo, Nahoum G. Anthony, Giacomo Berretta, Good, James A. D.,, Good, James A. D., Simon P. Mackay, Anthony, Nahoum G., James A. D. Good, Mackay, Simon P.   +8 more
core   +1 more source

Receptor–Ligand Interaction-Based Virtual Screening for Novel Eg5/Kinesin Spindle Protein Inhibitors

, 2016
Eg5/KSP is a promising mitotic spindle target for drug discovery in cancer chemotherapy and the development of agents against fungal diseases. A range of Eg5 targeting compounds identified by in vitro or cell-based screening is currently in development ...
Ae Nim Pae (806345), Frank Kozielski (1283658), Shanthi Nagarajan (29553), Dimitrios A. Skoufias (173868)   +3 more
core   +1 more source

The Activity of eg5 and Dynein During Mammalian Mitosis

, 2009
The development and maintenance of multicellular organisms depends fundamentally on cell division, a series of events largely mediated by the mitotic spindle. Errors in spindle formation and/or function are often associated with severe consequences, most
Ferenz, Nicholas P.
core   +1 more source

Study on the highly efficient photoregulation of mitotic kinesin Eg5 using novel photo-chromic inhibitor

, 2018
創価大学博士（工学）Living cell is composed of millions of densely packed biomolecules that perform so many tasks to constitute life. Recently, the structure and function of the biomolecules that have a key role in cell motility have been clarified.
Sadakane, Kei, 貞包, 慧
core  

Teneurin-2 and related proteins in reactive astrocytes after <i>status epilepticus</i> induction in adult rats. [PDF]

Front Neurosci
Tessarin GWL, Hogg DW, Gonçalves A, Casatti DV, Savenhago VM, da Costa BSS, Priore VBD, Lovejoy DA, Horta-Junior JAC, Casatti CA.   +9 more
europepmc   +1 more source

Mitotic Machinery Dysregulation in Lung Cancer: Biological Roles, Therapeutic Targeting, and Combination Strategies. [PDF]

Pharmaceutics
Pinto B, Silva JPN, Silva PMA, Sarmento B, Carvalho-Tavares J, Bousbaa H.   +5 more
europepmc   +1 more source

Insights into KIF11 pathogenesis in microcephaly-lymphedema-chorioretinopathy syndrome from a lymphatic perspective. [PDF]

JCI Insight
Ogmen K, Dobbins SE, Behncke RY, Martinez-Corral I, Brown RC, Meier M, Ulferts S, Hansmeier NR, Sackey E, Alqahtani A, Karapouliou C, Grigoriadis D, Del Rey Jimenez JC, Oberlin M, Williams D, Ekici A, Karaer K, Jeffery S, Mortimer P, Gordon K, Okuda KS, Hogan BM, Mäkinen T, Hägerling R, Mansour S, Martin-Almedina S, Ostergaard P.   +26 more
europepmc   +1 more source