Results 21 to 30 of about 8,462,139 (217)
Kinesin-5 mediated chromosome congression in insect spindles. [PDF]
Cell Mol Bioeng, 2018 The microtubule motor protein kinesin-5 is well known to establish the bipolar spindle by outward sliding of antiparallel interpolar microtubules. In yeast, kinesin-5 also facilitates chromosome alignment "congression" at the spindle equator by preferentially depolymerizing long kinetochore microtubules (kMTs). The motor protein kinesin-8 has also been
Tubman E, He Y, Hays TS, Odde DJ.
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A conserved role for kinesin-5 in plant mitosis [PDF]
Journal of Cell Science, 2007 The mitotic spindle of vascular plants is assembled and maintained by processes that remain poorly explored at a molecular level. Here, we report that AtKRP125c, one of four kinesin-5 motor proteins in arabidopsis, decorates microtubules throughout the cell cycle and appears to function in both interphase and mitosis. In a temperature-sensitive mutant,
Bannigan, Alex +6 more
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Kinesin-5 acts as a brake in anaphase spindle elongation [PDF]
Current Biology, 2007 SummaryBipolar kinesin-5 motors, essential in diverse organisms, can generate positive sliding forces between overlapped interpolar microtubules to push mitotic spindle poles apart. BMK-1, the sole Caenorhabditis elegans kinesin-5, is not essential. We have determined, by tracking pole movements in bmk-1 mutant C.
Saunders, Adam M. +3 more
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The bipolar assembly domain of the mitotic motor kinesin-5 [PDF]
Nature Communications, 2013 An outstanding unresolved question is how does the mitotic spindle utilize microtubules and mitotic motors to coordinate accurate chromosome segregation during mitosis? This process depends upon the mitotic motor, kinesin-5, whose unique bipolar architecture, with pairs of motor domains lying at opposite ends of a central rod, allows it to crosslink ...
Acar, Seyda +11 more
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The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner. [PDF]
J Biol Chem, 2017 Kinesin motors play central roles in establishing and maintaining the mitotic spindle during cell division. Unlike most other kinesins, Cin8, a kinesin-5 motor in Saccharomyces cerevisiae, can move bidirectionally along microtubules, switching directionality according to biochemical conditions, a behavior that remains largely unexplained.
Bell KM +3 more
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'Mitotic' kinesin-5 is a dynamic brake for axonal growth in Drosophila.
DevelopmentABSTRACT During neuronal development, microtubule reorganization shapes axons and dendrites, establishing the framework for efficient nervous system wiring. Our previous work has demonstrated the role of kinesin-1 in driving microtubule sliding, which powers early axon outgrowth and regeneration in Drosophila melanogaster.
Lu W +5 more
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Mitotic functions of kinesin-5 [PDF]
Seminars in Cell & Developmental Biology, 2010 In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the
Ferenz, NP, Gable, A, Wadsworth, P
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Effect of the Neck Linker on Processive Stepping of Kinesin Motor
Biophysica, 2023 Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
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owolff-MPImF/MINFLUX-tracking-of-Kinesin-1-2022: MINFLUX data processing and evaluation
, 2022 Matlab files for processing raw MINFLUX data using a fixed-curvature or sliding-curvature estimator. Additional files for detecting steps in noisy data and for determining the bound and unbound state of the labeled kinesin ...
MINFLUX tracking of kinesin-1 2022
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BMC Research Notes, 2009 Background Kinesin-5 (Eg-5) motor proteins are essential for maintenance of spindle bipolarity in animals. The roles of Kinesin-5 proteins in other systems, such as Arabidopsis, Dictyostelium, and sea urchin are more varied.
Miller Anne +2 more
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