Results 41 to 50 of about 8,462,139 (217)
, 2022 Live cell imaging showing location of kinesin-13GFP (green) with respect to kinetochore marker NDC80Cherry (red) during asexual (A, B) and sexual (C, D) proliferative stages.
Anthony A. Holder (53358) +11 more
core +1 more source
Chromosome 20q Amplification Regulates Response to Kinesin-5 Inhibitor
Cancer Informatics, 2008 We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines.
Aimee L. Jackson +7 more
doaj +1 more source
FEBS Open Bio, 2021 Motile kinesins are motor proteins that translocate along microtubules as they hydrolyze ATP. They share a conserved motor domain which harbors both ATPase and microtubule‐binding activities.
Paloma F. Varela +5 more
doaj +1 more source
Kinesin-5: A Team Is Just the Sum of Its Parts [PDF]
Developmental Cell, 2015 How the cell builds a spindle remains an open question. In this issue of Developmental Cell, Shimamoto, Forth, and Kapoor (2015) show that kinesin-5 motor ensembles can exert sliding forces that scale with microtubule overlap length. This behavior could allow microtubule architecture-dependent modulation of force and contribute to spindle self ...
Hueschen, Christina L +2 more
openaire +4 more sources
Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers
eLife, 2014 Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod.
Jessica E Scholey +3 more
doaj +1 more source
Understanding the Conformational Changes of Kinesin‐5
The FASEB Journal, 2020 Human Kinesin‐5 (Eg5), an anticancer drug target, is key to the assembly of the bipolar spindle during mitosis. Its promise as a clinical target comes from the fact that it is involved only in metaphase and not interphase like some of the leading clinical drugs; however, the overall mechanism of inhibition ...
Kingston Robinson +3 more
openaire +1 more source
Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. [PDF]
PLoS ONE, 2008 BACKGROUND:Motor proteins from the kinesin-5 subfamily play an essential role in spindle assembly during cell division of most organisms. These motors crosslink and slide microtubules in the spindle.
Julie Cahu +8 more
doaj +1 more source
Kinesin-5 motors are required for organization of spindle microtubules in
BMC Plant Biology, 2006 Background Monastrol, a chemical inhibitor specific to the Kinesin-5 family of motor proteins, was used to examine the functional roles of Kinesin-5 proteins during the first, asymmetric cell division cycle in the brown alga Silvetia compressa.
Kropf Darryl L, Peters Nick T
doaj +1 more source
Kinesin-II motility under crowded conditions.
, 2020 A. Schematic of the in vitro motility assay. kinesin-II motors walk along the microtubules attached to the glass slide. The fluorescently labeled motor proteins are excited and imaged using TIRF microscopy. B.
Daniël M. Miedema (8447271) +5 more
core +1 more source
Development of a Drosophila cell-based error correction assay
Frontiers in Oncology, 2013 Accurate transmission of the genome through cell division requires microtubules from opposing spindle poles to interact with protein super-structures called kinetochores that assemble on each sister chromatid.
Jeffrey D. Salemi +3 more
doaj +1 more source