Results 51 to 60 of about 8,462,139 (217)

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]

, 2006
The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
James E. Evans, Kent L. McDonald, Amy L. Gunnarson, Gunnarson, Amy L., Guangshuo Ou, Snow, JJ, McDonald, KL, Stahlberg, Henning, Ou, Guangshuo, Ou, GS, Evans, JE, Stahlberg, H, Evans, James E., Jonathan M. Scholey, Scholey, JM, Gunnarson, AL, McDonald, Kent L., Joshua J. Snow, Henning Stahlberg, Snow, Joshua J., Scholey, Jonathan M.   +20 more
core   +1 more source

Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection.

, 2022
Intracellular mature virus (IMV) are the first and most abundant infectious form of vaccinia virus to assemble during its replication cycle. IMV can undergo microtubule-based motility, but their directionality and the motor involved in their transport ...
Timothy P Newsome (13916763), Amadeus Xu (13916760), Angika Basant (4376254), Sibylle Schleich (371798), Michael Way (255647)   +4 more
core   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

Angewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni, Jessica Groppi, Alberto Credi, Serena Silvi   +3 more
wiley   +2 more sources

Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism

Neural Regeneration Research, 2015
Microtubules have been identified as a powerful target for augmenting regeneration of injured adult axons in the central nervous system. Drugs that stabilize microtubules have shown some promise, but there are concerns that abnormally stabilizing ...
Peter W Baas, Andrew J Matamoros
doaj   +1 more source

Kinesin-5 reins in axon branching [PDF]

The Journal of Cell Biology, 2007
The motor that puts a brake on spindle microtubule sliding also decelerates axon branching, report Myers and Baas.
openaire   +1 more source

Understanding the Sequence of Chemomechanical Transitions in Kinesin-5 [PDF]

Biophysical Journal, 2016
The kinesin-5 KSP/Eg5 pauses at microtubule plus-ends and enhances tubulin polymerization by increasing the growth rate and decreasing the catastrophe rate (Chen et al. 2015). The end pausing resembles that of the kinesin-8, kip3p, but has the opposite effect on microtubule dynamics.
Chen, Geng-Yuan, Hancock, William O.
openaire   +1 more source

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

eLife, 2014
Microtubule-based transport by the kinesin motors, powered by ATP hydrolysis, is essential for a wide range of vital processes in eukaryotes. We obtained insight into this process by developing atomic models for no-nucleotide and ATP states of the ...
Zhiguo Shang, Kaifeng Zhou, Chen Xu, Roseann Csencsits, Jared C Cochran, Charles V Sindelar   +5 more
doaj   +1 more source

Control of Directionality of Individual Kinesin-5 Motors [PDF]

Biophysical Journal, 2012
Kinesin-5 motors fulfill essential roles in mitotic spindle morphogenesis and dynamics as slow, processive microtubule (MT)-plus-end directed motors. The Saccharomyces cerevisiae kinesin-5 Cin8 was found, surprisingly, to switch directionality. Here we have examined Cin8 directionality control using single-molecule fluorescence motility assays and live-
Gerson-Gurwitz, Adina, Thiede, Christina, Movshovich, Natalia, Fridman, Vladimir, Podolskaya, Maria, Lakaemper, Stefan, Klopfenstein, Dieter R., Schmidt, Christoph F., Gheber, Larisa   +8 more
openaire   +2 more sources

The location of kinesin-5 and kinesin-8X in relation to that of kinetochore (NDC80) and axoneme marker (kinesin-8B).

, 2022
(A) Live cell images of gametocytes showing dual lines expressing either kinesin-5GFP or NDC80-mCherry/kinesin-8BmCherry or both in the same gametocyte.
Anthony A. Holder (53358), Rita Tewari (134257), Sue Vaughan (20216), Steven Abel (7484636), Zeinab Chahine (13170045), Ravish Rashpa (4278514), Mohammad Zeeshan (141644), Carolyn A. Moores (7484654), Karine G. Le Roch (7373171), David J. P. Ferguson (7484639), Declan Brady (134247), Mathieu Brochet (149272)   +11 more
core   +1 more source

A Structural Model of the Kinesin-5 Mechanochemical Cycle [PDF]

Biophysical Journal, 2014
Kinesin motor domains drive diverse microtubule-based, ATP-dependent activities but the molecular adaptations that specify these diverse functions are poorly understood. Kinesin-5s are essential mitotic motors and their inhibition with specific small molecules blocks cell division.
Moores, Carolyn A., Goulet, Adeline, Major, Jennifer, Jun, Yonggun, Gross, Steven, Rosenfeld, Steven   +5 more
openaire   +1 more source