Results 31 to 40 of about 8,462,139 (217)
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]
, 2014 Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S +13 more
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Regulation of Activity of the Kinesin-5 CIN8 [PDF]
Biophysical Journal, 2017 The homoterameric bipolar kinesin-5 motors perform essential functions in mitotic spindle dynamics by crosslinking and sliding apart antiparallel microtubules. S. cerevisiae cells express two kinesin-5s Cin8 and Kip1, which overlap in function. We have recently demonstrated that Cin8 and Kip1 are minus-end directed on the single-molecule level and can ...
Larisa Gheber +6 more
openaire +1 more source
Kinesin-14 : the roots of reversal [PDF]
, 2010 Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross, R. A. +2 more
core +1 more source
BMC Plant Biology, 2021 Background Kinesin (KIN) as a motor protein is a versatile nano-machine and involved in diverse essential processes in plant growth and development. However, the kinesin gene family has not been identified in watermelon, a valued and nutritious fruit ...
Shujuan Tian +7 more
doaj +1 more source
Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G. +5 more
core +1 more source
Spindle Assembly: Kinesin-5 Is in Control [PDF]
Current Biology, 2008 Kinesin-5 is essential in many species for the formation of a bipolar spindle. Although bipolar tetramers were known to crossbridge pairs of microtubules, the mechanism for organizing spindles was unclear. However, new experiments have revealed unique properties of kinesin-5, including some associated with the tail domain, that provide clues as to how ...
openaire +2 more sources
, 2022 (A) Expansion microscopy showing colocalisation of kinesin-13 (green) with α/β tubulin staining (purple) in gametocytes activated for 15 min. Scale bar = 5 μm.
Anthony A. Holder (53358) +11 more
core +1 more source
Nature Communications, 2017 Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule ...
Sergio A. Rincon +7 more
doaj +1 more source
Inhibitors of Human Kinesin‐5 do not inhibit the Drosophila Kinesin‐5 protein
The FASEB Journal, 2006 Kinesin‐5 motor proteins are vital for formation of the mitotic spindle in all eukaryotic cells. To date several small molecules have been discovered that inhibit certain Kinesin‐5 proteins (Human, Xenopus) but not others (Aspergillus). The specific structural interactions that make one Kinesin‐5 susceptible to inhibition but another insensitive have ...
Sarah Ann Sebring +4 more
openaire +1 more source
Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]
, 2000 The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Mandelkow, Eckhard +6 more
core +1 more source