Electrostatically biased binding of kinesin to microtubules. [PDF]
PLoS Biology, 2011 The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Barry J Grant +7 more
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Single‐headed mode of kinesin‐5 [PDF]
EMBO reports, 2008 In most organisms, kinesin‐5 motors are essential for mitosis and meiosis, where they crosslink and slide apart the antiparallel microtubule half‐spindles. Recently, it was shown using single‐molecule optical trapping that a truncated, double‐headed human kinesin‐5 dimer can step processively along microtubules.
Kuniyoshi, Kaseda +3 more
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The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding [PDF]
eLife, 2020 Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament.
Tatyana Bodrug +17 more
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The Kinesin-12 Kif15 is a processive track-switching tetramer [PDF]
eLife, 2014 Kinesin-12 motors are a little studied branch of the kinesin superfamily with the human protein (Kif15) implicated in spindle mechanics and chromosome movement.
Hauke Drechsler +4 more
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Mitotic Motors: Kinesin-5 Takes a Brake [PDF]
Current Biology, 2007 A kinesin-5-dependent 'sliding filament' mechanism is commonly used to actively push apart the poles during mitotic spindle assembly and elongation, but a recent study now shows that, in C. elegans, kinesin-5 is deployed as a brake to slow down spindle-pole separation.
Civelekoglu-Scholey, Gul +1 more
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Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes [PDF]
Cell Division, 2020 Background Microtubule organization is essential for bipolar spindle assembly and chromosome segregation, which contribute to genome stability. Kinesin-5 Eg5 is known to be a crucial regulator in centrosome separation and spindle assembly in mammalian ...
Zhen-Yu She +7 more
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Kinesin-5 Is Essential for Growth-Cone Turning [PDF]
Current Biology, 2008 Inhibition of kinesin-5, a mitotic motor protein also expressed in neurons, causes axons to grow faster as a result of alterations in the forces on microtubules (MTs) in the axonal shaft. Here, we investigate whether kinesin-5 plays a role in growth-cone guidance. Growth-cone turning requires that MTs in the central (C-) domain enter the peripheral (P-)
Nadar, Vidya C. +4 more
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Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe [PDF]
G3: Genes, Genomes, Genetics, 2019 The Kinesin-5 motor Cut7 in Schizosaccharomyces pombe plays essential roles in spindle pole separation, leading to the assembly of bipolar spindle. In many organisms, simultaneous inactivation of Kinesin-14s neutralizes Kinesin-5 deficiency.
Masashi Yukawa +2 more
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Force Dependence of Velocity and Run Length of Kinesin-1, Kinesin-2 and Kinesin-5 Family Molecular Motors [PDF]
Molecules, 2019 Kinesin-1, kinesin-2 and kinesin-5 are three families of a superfamily of motor proteins; which can walk processively on microtubule filaments by hydrolyzing ATP. It was experimentally shown that while the three kinesin dimers show similar feature on the
Si-Kao Guo +3 more
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Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other [PDF]
The EMBO JournalDuring mitosis, motor proteins and microtubule-associated protein organize the spindle apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle formation and maintenance, potentially inducing twist in the spindle ...
Laura Meißner +4 more
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