Results 81 to 90 of about 447,577 (315)
Direct comparison of 3 PCR methods in detecting EGFR mutations in patients with advanced non-small-cell lung cancer [PDF]
, 2012 Epidermal growth factor receptor (EGFR) mutations are predictive of response to EGFR tyrosine kinase inhibitors (TKIs) in NSCLC. Several methods have been used to detect EGFR mutations; however, it is not clear which is the most suitable for use in the ...
Tomonaga, Nanae +11 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Development of a novel EGFR-targeted peptide for targeted delivery of drugs in anaplastic thyroid cancer [PDF]
, 2023 peer reviewedAnaplastic thyroid carcinoma (ATC) represents the most aggressive and deadliest thyroid cancer in human with a high proliferative and metastatic potential. The median survival of patients with ATC is of about 4 months after diagnosis and the
Journe, Fabrice +7 more
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Pharmacogenomics and Personalized Medicine, 2021 Zhang L, Li X, Lu J, et al. Pharmgenomics Pers Med. 2021;14:469–476. Page 470, Materials and Methods, Clinical Samples, second sentence, the text “All blood samples are taken from Liyang People’s Hospital during March 2009 to August ...
Zhang L +6 more
doaj
Исследования и практика в медицине, 2019 Purpose of the study. The purpose of the study was to find the difference between local levels of VEGF, EGF, IGFI and IG- FII in tumor and intact tissues in adenocarcinoma of the stomach (AC) and signet-ring cell carcinoma of the stomach (SRCC).Materials
O. I. Kit +10 more
doaj +1 more source
EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors [PDF]
Clinical Cancer Research, 2015 Abstract Purpose: Mutant selective irreversible pyrimidine-based EGFR kinase inhibitors, including WZ4002, CO-1686, and AZD9291, are effective in preclinical models and in lung cancer patients harboring the EGFR T790M gefitinib/erlotinib resistance mutation.
Dalia, Ercan +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Chemistry & Biology, 2015 The ErbB family is a subfamily of receptor tyrosine kinases (RTKs). In RTKs, ligand binding at the extracellular region triggers diverse cytoplasmic signaling cascades. Exactly how ligand binding is translated into specific signaling outcomes remains incompletely understood. In this issue, Doerner et al.
Kennedy, Eileen J., Kannan, Natarajan
openaire +2 more sources
Synthesis of indolinone-based derivatives for liposomal insertion in active targeting against EGFR.
, 2022 reservedSulla base dei risultati ottenuti a seguito di un precedente progetto di ricerca svolto presso il Dipartimento di Scienze del Farmaco, l'obiettivo di questo lavoro di tesi sperimentale consta nella sintesi di derivati a base indolinonica ...
NEGRI, STEFANO
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