Results 141 to 150 of about 447,577 (315)

EGFR-TKI combination treatment for NSCLC with EGFR-sensitive mutation

Expert Review of Anticancer Therapy
Lung cancer is the leading cause of cancer-related deaths. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have opened up a new therapeutic avenue for EGFR-sensitive mutated non-small cell lung cancer (NSCLC), but their resistance is unavoidable. Overcoming the resistance is desperately desired. Combined treatments are partially
Yuanqiang, Wu, Yunfei, Li, Lorraine Edna, Onzere, Weini, Quan, Xueqing, Zhang, Jin'an, Ma   +5 more
openaire   +2 more sources

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

To eGFR or not to eGFR: here is an intern's answer [PDF]

Kidney International, 2009
openaire   +2 more sources

Regulation of EGF receptor trafficking by the lysine deacetylase HDAC6

, 2010
Epidermal growth factor (EGF) receptor belongs to the broad family of enzymatic receptors called receptor tyrosine kinases (RTKs). Generally, the binding of a ligand to these receptors leads to activation of their intracellular kinase activity that sets ...
Deribe, Yonathan Lissanu
core  

Second-Line Treatments after First-Line Gefitinib Therapy in Advanced Nonsmall Cell Lung Cancer

, 2011
Gefitinib is effective as first-line therapy for advanced nonsmall cell lung cancer (NSCLC). However, after failure of gefitinib, it is unknown whether any second-line regimens could lead to better outcomes.
WU, JENN-YU;SHIH, JIN-YUAN;YANG, CHIH-HSIN;CHEN, KUAN-YU;HO, CHAO-CHI;YU, CHONG-JEN;YANG, PAN-CHYR, 巫震宇;施金元;楊志新;陳冠宇;何肇基;余忠仁;楊泮池   +1 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Nanoparticle-based targeted therapy through EGFR tyrosine kinase inhibitors and their recent advances in lung cancer therapy

Exploration of Medicine
The emergence and subsequent advancement of nanotechnology in recent years have greatly benefited the healthcare sector, particularly in the treatment of cancer. As per study, major fatalities are related to the lung cancer. For many years, oral tyrosine
Priyanka S. Waghmare, Anuruddha R. Chabukswar, Kunal G. Raut, Bhagyashree Gaikwad-Pawar, Swati C. Jagdale   +4 more
doaj   +1 more source

Reporting eGFR [PDF]

Clinical Journal of the American Society of Nephrology, 2008
openaire   +2 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Progress of Microsatellite (GT/CA)n Repeat Polymorphisms in Non-small Cell Lung Cancer

Zhongliu Fangzhi Yanjiu
Non-small cell lung cancer (NSCLC) is the most important histological type of lung cancer. This disease affects a large number of patients, and the prognosis of advanced patients is poor.
YANG Wenjun, FU Yuting, YUAN Yeqin, LIU Da, JIANG Binyuan   +4 more
doaj   +1 more source