Results 31 to 40 of about 447,577 (315)

Access to Diagnostics and Treatment for People With Metastatic EGFR-Positive NSCLC: Lessons From Project PRIORITY

JTO Clinical and Research Reports
Introduction: The treatment landscape for people diagnosed with EGFR-mutated (EGFR-m) NSCLC has rapidly evolved, yet there remains limited self-reported information about the lived experience.
Jill Feldman, MA, Ivy Elkins, MBA, Zofia Piotrowska, MD, Bellinda L. King-Kallimanis, PhD, Tendai Chihuri, MD, Carly Johnson, BS, Alecia Clary, PhD, Teri Kennedy, MA, Upal Basu Roy, PhD, MPH   +8 more
doaj   +1 more source

Expressions of TP53, PDGF and EGFR in Primary Astrocytomas and Their Correlation with Clinicopathological Features and Prognosis

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the expression of TP53, PDGF and EGFR in primary astrocytomas, and analyze their correlation with clinicopathological features and prognosis.
SUN Xiaoling, ZHANG Xiaojuan, ZHANG Qingquan, QIU Lei, WANG Linna, HOU Suping   +5 more
doaj   +1 more source

THE IMPORTANCE OF DETERMINING THE UROMODULIN SERUM CONCENTRATION IN DIABETES MELLITUS TYPE 2 PATIENTS

Sanamed, 2021
Introduction: In the kidney, cells in the thick ascending limb of the loop of the Henle synthesized uromodulin (UMOD). This study aims to present the evaluation of the uromodulin serum concentration in diabetes mellitus type 2 (T2DM) patients in the ...
Jordanova Elena, Samardzic Vladimir, Pekovic-Perunicic Gordana, Tica-Jevtic Jelena, Simic-Ogrizovic Sanja   +4 more
doaj   +1 more source

EGFR-MET interaction is modulated by EGFR mutations.

, 2017
(A) Western blot (WB) of total MET levels in H1975 derived cells. Tubulin levels are shown as loading control. Values beneath blots are relative levels of MET compared to the total levels in the H1975L858R/T790M cell line from 2 independent experiments +/
Elena Ortiz-Zapater (3708226), Michael J. Neat (3708214), William Owen (3708211), Frank McCaughan (3708217), Richard W. Lee (3708220), Gilbert Fruhwirth (1886137), Peter Parker (668602), Robert G. Dunn (3708223), George Santis (210710), Gregory Weitsman (172342), Tony Ng (172369)   +10 more
core   +1 more source

Transforming Growth Factor Alpha Stimulation of Mucosal Tissue Cultures from Head and Neck Squamous Cell Carcinoma Patients Increases Chemoresistance to Cisplatin [PDF]

, 2010
The monoclonal epidermal growth factor receptor ( EGFR) antibody cetuximab (Erbitux(TM)) was recently approved by the European Medicines Agency for the treatment of recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) in combination ...
Baumeister, Philipp, Ulrich Harréus, Schwenk-Zieger, Sabina, Maximilian Reiter, Philipp Baumeister, Reiter, Maximilian, Sabina Schwenk-Zieger, Harreus, Ulrich   +7 more
core   +1 more source

Antitumor Efficacy and Mechanisms of Lapatinib in Combination with Cisplatin on Esophageal Squamous Cancer Cells

Zhongliu Fangzhi Yanjiu, 2019
Objective To evaluate the antitumor efficacy of lapatinib in combination with cisplatin on esophageal squamous cell carcinoma (ESCC) and related mechanisms.
DOU Qiaohua, GUO Xiaofang, ZHU Xiaofei, ZHANG Yueyue, YANG Fan   +4 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Gormand, A, Adriaens, M.E., Adriaens, Michiel E., Kolch, W, Amelie Gormand, Adriaens, ME, Gormand, A., Sturm, OE, David R Gilbert, Richard J Orton, Walter Kolch, Orton, RJ, Orton, Richard J., Oliver E Sturm, Gilbert, D, Gilbert, David R., Michiel Adriaens, M.E., Michiel E Adriaens, Orton, R.J., Kolch, Walter, Kolch, W., Gilbert, D.R., Sturm, O.E., Sturm, Oliver E., et al., Gormand, Amelie   +25 more
core   +2 more sources

Role of EGFR Juxtamembrane Domain in EGFR Activation [PDF]

Biophysical Journal, 2011
The intracellular juxtamembrane domain of several receptor tyrosine kinases (RTKs) has been proposed to play an autoinhibitory role. The epidermal growth factor receptor (EGFR) has been widely used as a model in studies of the RTK activation mechanism.
He, Lijuan, Agudelo, Sandra C., Hristova, Kalina   +2 more
openaire   +1 more source

EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy

, 2020
meta-Tetra­(hydroxyphenyl)­chlorin (mTHPC) is one of the most potent second-generation photosensitizers, clinically used for photodynamic therapy (PDT) of head and neck squamous cell carcinomas.
Javier Sastre Toraño (1685377), Cornelus F. van Nostrum, Wim E. Hennink (290165), Marcel H. A. M. Fens, Irati Beltrán Hernández (8575506), Irati Beltrán Hernández, Julia Denise Peterson, Sabrina Oliveira (21108), Julia Denise Peterson (8575503), Marcel H. A. M. Fens (7105697), Bárbara Mesquita, Yanna Liu, Luca Scrivano (8575500), Sabrina Oliveira, Yanna Liu (16008), Cornelus F. van Nostrum (8298339), Luca Scrivano, Javier Sastre Toraño, Wim E. Hennink, Bárbara Mesquita (8575509)   +19 more
core   +1 more source

Joint co-clustering: co-clustering of genomic and clinical bioimaging data [PDF]

, 2007
For better understanding the genetic mechanisms underlying clinical observations, and better defining a group of potential candidates for protein-family-inhibiting therapy, it is interesting to determine the correlations between genomic, clinical data ...
Benini, L., De Micheli, Giovanni, Enrico Macii, Benini, Luca, G. De Micheli, S. Yoon, Yoon, S., E. Macii, Sungroh Yoon, DE MICHELI G, Elisa Ficarra, Giovanni De Micheli, Ficarra, Elisa, YOON S, E. Ficarra, Macii, Enrico, Yoon, Sungroh, De Micheli, G., Luca Benini, BENINI L   +19 more
core   +1 more source