Results 121 to 130 of about 447,577 (315)

Structure and molecular interaction analysis of monoclonal antibodies in complex with receptor tyrosine kinases

, 2010
Misregulated receptor tyrosine kinases (RTKs), i.e. the epidermal growth factor receptor EGFR or the insulin-like growth factor receptor 1 (IGF-1R), can be involved in the development of cancer.
Schmiedel, Judith
core  

Purified venom components inhibit EGFR phosphorylation in triple negative breast cancer [PDF]

, 2022
: EACR22-0963 Introduction Breast cancer remains the most commonly diagnosed type of cancer in both menopausal age women and adolescent/young adults. 10-20% of diagnosed breast cancers are deemed to be triple negative (TN), lacking expression of hormone
Trim, S., Trim, C., Mccullough, D., Baker, S.   +3 more
core  

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

Prevalence of Nucleotide Alterations of EGFR Gene in Patients with Esophageal Squamous Cell Carcinoma in Kerman [PDF]

Journal of Kerman University of Medical Sciences, 2012
Background & Aims: Esophageal Cancer is the sixth fatal cancer in the world. Squamous and adenocarcinoma account for 95% of esophageal cancer. The expression of EGFR has a role in the pathophysiology of epidermal-based malignancies such as esophageal ...
M.R Lashkarizadeh, M.R Bazrafshani, M Aghaei-Afshar, Neda Zahiri, S Dehghan-Kohestani   +4 more
doaj  

Expresión de mucinas y moléculas relacionadas en los carcinomas mucoepidermoides de glándulas salivales: implicaciones diagnósticas y pronósticas [PDF]

, 2011
[spa] El carcinoma mucoepidermoide, es el tumor maligno más frecuente de glándulas salivales (GS). Tanto su expresión de mucinas, MUC1 y MUC4, como el número de copias del gen EGFR (receptor del Factor de Crecimiento Epidérmico) y la expresión de pERK1/2
Luján, Blanca Noemí
core  

Pharmacology and advances in the field of EGFR inhibitors for the treatment of NSCLC

, 2023
Since the approval of the first epidermal growth factor receptor (EGFR) inhibitor for the treatment of non-small cell lung cancer (NSCLC) in 2003, great strides have been made in this field of targeted therapy to address the global burden of lung cancer,
Fakhoury, Omar
core  

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh, Dalia Sriwi, Callie Saric, Tripti Singh, Christie M. Bartels, Shivani Garg   +5 more
wiley   +1 more source

A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells

Drug Design, Development and Therapy, 2022
Mustofa,1 Pamungkas Bagus Satriyo,1 Artania Adnin Tri Suma,2 Stephanus Satria Wira Waskitha,3 Tutik Dwi Wahyuningsih,3 Eti Nurwening Sholikhah1 1Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Universitas Gadjah ...
Mustofa, Satriyo PB, Suma AAT, Waskitha SSW, Wahyuningsih TD, Sholikhah EN   +5 more
doaj  

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source