Results 151 to 160 of about 1,701,635 (388)
HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer
Advanced Science, EarlyView.This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su +13 more
wiley +1 more source
Advanced Science, EarlyView.PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li +6 more
wiley +1 more source
Advanced Science, EarlyView.Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou +9 more
wiley +1 more source
The future of the Dutch egg processing industry [PDF]
This research examines the competitiveness of the Dutch egg products industry, as well as the consequences of tightening up the laws concerning layer poultry on the competitive position of the Dutch egg production industry.
Cotteleer, Geerte +2 more
core +1 more source
APPLIANCE REGULATOR OF LAMP AND AUTOMATIC REVERSER AT BOX HATCH OF EGG BASED MICROCONTROLLER ATMEGA 16 EQUIPED BY UNINTERRUPTIBLE POWER SUPPLY . [PDF]
, 2012 Making of this final project aim to to get an periph eral in the form of appliance regulator of lamp and reverser of automatic egg at box hatch of egg with UPS digitally, which its use much more practical than which still is conventional.
Ichsan, Dwi Nugroho
core
Advanced Science, EarlyView.This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin +7 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that specific genetic variations in gut‐residing Saccharomyces cerevisiae significantly extend healthspan and lifespan in Drosophila melanogaster. These mutants rejuvenate aged intestinal metabolism, upregulate mitochondrial proteins, and enhance energy pathways.
Liying Wang +11 more
wiley +1 more source
Making Your Nest Egg Last a Lifetime [PDF]
Media attention on retirement security generally focuses on the need to save enough to enjoy a comfortable retirement. However, accumulating a nest egg is no longer the only significant challenge – the other is managing one’s nest egg in retirement.
Anthony Webb
core +1 more source