Results 81 to 90 of about 8,038 (216)
SP0119 The evolving role of mepolizumab in egpa [PDF]
Annals of the Rheumatic Diseases, 2018 There is overwhelming evidence that eosinophiles play a key role in the pathogenesis of EGPA. Il-5 is the central cytokine for eosinophil maturation, eosinophil release from the bone marrow and eosinophil survival. Mepolizumab is an antibody neutralising IL-5, which proved efficient in the hypereosinophilic syndrome and eosinophilc asthma, amongst ...
openaire +1 more source
Blood Leukocyte Characterisation in Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Introduction: Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare, autoimmune condition, preceded by asthma and/or chronic rhinosinusitis symptoms, later developing blood and tissue eosinophilia, along with vasculitis and granuloma formation ...
Rebecca B. Dale (22309928)
core +1 more source
Recalcitrant steroid-resistant EGPA with multisystem involvement
, 2017 Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystem disorder classically characterized by sequential histopathologic and clinical disease phases. An eosinophilic tissue infiltration phase typically precedes the development of a systemic
Gerard Cox +4 more
core +1 more source
A role for IL-33–activated ILC2s in eosinophilic vasculitis
JCI Insight, 2021 Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare but serious disease with poorly understood mechanisms. Here, we report that patients with EGPA have elevated levels of TSLP, IL-25, and soluble ST2, which are well-characterized cytokine ...
Maya E. Kotas +8 more
doaj +1 more source
181. Tissue immunophenotyping of three refractory cases of EGPA using single cell RNA sequencing
, 2022 Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a multisystem inflammatory disorder currently classified as an Antineutrophil Cytoplasmic Antibody (ANCA) associated vasculitis.
David Jayne1, Matthew Coates1
core +1 more source
Frontiers in ImmunologyBackgroundOverlap between rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) (“rhupus”) is recognized, but coexistence with a severe eosinophilic asthma syndrome is exceptionally rare. We describe a triple autoimmune overlap of RA, SLE, and
Ji Li +7 more
doaj +1 more source
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management [PDF]
, 2015 Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA).
Bottero, P. +46 more
core +1 more source
ReumatismoBackground. Early diagnosis of Eosinophilic Granulomatosis with Polyangiitis (EGPA) remains one of the major unmet needs in clinical practice due to the non-specific nature of prodromal symptoms and the lack of specific biomarkers, particularly in ...
Società Italiana di Reumatologia
doaj
Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Acta Medica, 2021 Abdurrahman Tufan, Hazan Karadeniz
openaire +2 more sources
, 2017 Introduction: Eosinophilic granulomatosis with polyangiitis (EGPA) is an uncommon systemic necrotizing vasculitis that affects small to medium sized vessels and is associated with severe asthma, allergic rhinitis, nasal polyposis and blood and tissue ...
AGOSTINI, CARLO +9 more
core +1 more source