Results 111 to 120 of about 111,930 (282)

Escape Route Index: A Spatially-Explicit Measure of Wildland Firefighter Egress Capacity

Fire, 2019
For wildland firefighters, the ability to efficiently evacuate the fireline is limited by terrain, vegetation, and fire conditions. The impacts of terrain and vegetation on evacuation time to a safety zone may not be apparent when considering potential ...
Michael J. Campbell, Wesley G. Page, Philip E. Dennison, Bret W. Butler   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Pathways of host cell exit by intracellular pathogens

Microbial Cell, 2018
Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to barrier penetration, tissue dissemination, inflammation, and pathogen transmission.
Antje Flieger, Freddy Frischknecht, Georg Häcker, Mathias W. Hornef, Gabriele Pradel   +4 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Adaptive Kinetic Architecture and Collective Behavior: A Dynamic Analysis for Emergency Evacuation

Buildings, 2019
Adaptive kinetic architecture has emerged from a need for innovative designs that adapt to the environment and changing needs of the occupants. Architectural design and modes of egress are critical in an emergency. Flocking describes a certain collective
Angella Johnson, Size Zheng, Aiichiro Nakano, Goetz Schierle, Joon-Ho Choi   +4 more
doaj   +1 more source

Piezoelectric pump Patent [PDF]

, 1968
Piezoelectric pump for supplying fluid at high frequencies to gyroscope fluid suspension ...
Anderson, R. F.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Liberty Street School: Reuse and Rehabilitation Feasibility Report [PDF]

, 2012
It is recommended that the iron fire escapes on the east and west elevations be removed because they do not meet current fire codes as a proper means of egress from the building.
Deitz, Eric, Robinson, Arnold, Spears, Matt, Wikina, Nedith   +3 more
core   +1 more source

Pedestrian, Crowd, and Evacuation Dynamics

, 2013
This contribution describes efforts to model the behavior of individual pedestrians and their interactions in crowds, which generate certain kinds of self-organized patterns of motion. Moreover, this article focusses on the dynamics of crowds in panic or
A Borgers, A Johansson, A Johansson, A Mintz, A Seyfried, BD Hankin, BD Jacobs, C Burstedde, CW Reynolds, D Elliott, D Garbrecht, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, E Quarantelli, F Radjai, G LeBon, G Peng, GG Løvås, GH Ristow, GK Still, H Klüpfel, H-H Stølum, HH Kelley, HW Hamacher, I Rodríguez-Iturbe, J Kerridge, J Klockgether, J Pauls, J Surowiecki, J Tubbs, JJ Fruin, JL Bryan, JP Keating, K Ando, K Lewin, KR Sreenivasan, LF Henderson, LP Kadanoff, M Ebihara, M Fukui, M Isobe, M Muramatsu, ME Cates, N Ashford, N Ketchell, NE Miller, NE Miller, NJ Smelser, NR Johnson, NS Glance, P Bak, PA Johnson, PA Thompson, PG Gipps, R Axelrod, R Axelrod, R Brown, RH Turner, RL Hughes, S Ghashghaie, S Hoogendoorn, S Okazaki, SJ Older, SJ Yuhaski Jr, SP Hoogendoorn, T Baeck, T Kretz, T Schelling, Transportation Research Board, VJ Blue, VM Predtechenskii, WH Whyte   +87 more
core   +1 more source