Results 111 to 120 of about 48,176 (297)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress [PDF]

, 2016
T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are ...
Jung H. Suh, Julie D. Saba, Suh, Jung, Jesus Zamora-Pineda, Meng Zhang, Zamora-Pineda, Jesus, Saba, Julie, Ashok Kumar, Kumar, Ashok, Zhang, Meng   +9 more
core   +1 more source

Assembly and Egress of an Alphaherpesvirus Clockwork [PDF]

, 2017
All viruses produce infectious particles that possess some degree of stability in the extracellular environment yet disassemble upon cell contact and entry. For the alphaherpesviruses, which include many neuroinvasive viruses of mammals, these metastable virions consist of an icosahedral capsid surrounded by a protein matrix (referred to as the ...
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Emergency egress requirements for Space Station Freedom

, 1991
An objective was to determine if the pressurized elements and hatchways of the Space Station Freedom support the emergency egress of crewmembers during operation of the station at the stage of Permanently Manned Capacity.
Ray, Paul S.
core  

Simulated fire video collection for advancing understanding of human behavior in building fires

Frontiers in Psychology
IntroductionThe goal of the present research was to develop a video collection of simulated fires to investigate how people perceive growing building fires.
Justin W. Bonny, Zishanul Hussain, Micah D. Russell, Arnaud Trouvé, James A. Milke   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Defining Molecular Mechanism of Egress in Cryptosporidium

, 2021
Recent studies have identified Cryptosporidium as a major contributor to childhood disease in endemic areas. Current interventions are not ideal where only few have demonstrated anti-cryptosporidial activity and are often associated with relapses in ...
Nava, Samantha
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source