Results 41 to 50 of about 1,584,691 (217)

Antitumor activity of two Streptomyces extracts (Ag18 & Ag20) on Ehrlich ascites tumor in mice in vitro and in vivo studies [PDF]

Journal of Bioscience and Applied Research, 2015
This study aimed to evaluate the potent antitumor activity of metabolites from Streptomyces as antitumor activity using in vitro and in vivo studies. The Streptomyces were purely isolated from the soil samples, processed to obtain their extracts.
Amany Gaber, Osama Badr, Saad Emara, Atef Ibrahim   +3 more
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice

Tumor Biology, 2017
Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors.
Amina M Medhat, Khaled Sh Azab, Mahmoud M Said, Neama M El Fatih, Nermeen M El Bakary   +4 more
doaj   +1 more source

Anti-tumor therapy with macroencapsulated endostatin producer cells

BMC Biotechnology, 2010
Background Theracyte is a polytetrafluoroethylene membrane macroencapsulation system designed to induce neovascularization at the tissue interface, protecting the cells from host's immune rejection, thereby circumventing the problem of limited half-life ...
Balduino Keli N, Chura-Chambi Rosa M, da Costa Patrícia LN, Malavasi Natália V, Chammas Roger, Rodrigues Danielle B, Morganti Ligia   +6 more
doaj   +1 more source

Synthesis, Cytotoxicity, and Apoptosis‐Associated Cell Death Activity of an Isatin‐Containing Pyrimidine‐Derived Cu(II) Complex

Journal of Applied Toxicology, EarlyView.
ABSTRACT A Cu(II) complex derived from a pyrimidine with the isatin group was synthesized and tested for its cytotoxic effects on A549 lung cancer and MCF‐7 breast cancer cell lines, as well as its effects on apoptosis‐associated cell death and cell cycle regulation in A549 cells. To evaluate cytotoxicity, MTT assays were performed at 24, 48, and 72 h,
Müjgan Kesik Oktay, Cansu Topkaya, Elif Kağa, Yasin Eren, Ramazan Güp   +4 more
wiley   +1 more source

The Crude Venom of the Whitetail Lancehead, Bothrops leucurus, and Two of Its Enzymatic Components Are Selectively Cytotoxic for Glioma Cells In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Malignant glioma is the most common primary brain tumor, and glioblastoma multiforme (GBM) remains its most aggressive and incurable form. Snake venoms contain bioactive compounds with promising antitumoral properties against several cancer types.
M. O. H. V. Rosário, T. M. Fucase, P. J. Spencer, J. M. Sciani, J. Clarêncio, G. Rádis‐Baptista, L. L. Casais‐e‐Silva, R. S. El‐Bachá   +7 more
wiley   +1 more source

Balancing coherence and resonance through linguistic framing: A longitudinal study of German biotechnology ventures' responses to the Covid‐19 pandemic

Strategic Entrepreneurship Journal, EarlyView.
Abstract Research Summary Research suggests that ventures benefit from framing to gain audience support, yet how they utilize framing when exogenous shocks redirect attention remains unclear. Drawing on a longitudinal multiple‐case study of six biotechnology ventures following the COVID‐19 pandemic, we show how ventures balance coherence and resonance ...
Niklas Dreymann, Indre Maurer
wiley   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Antitumor effect of lysine-isopeptides

Cancer Cell International, 2002
Isopeptides (ε-peptides) of lysine, with a given Mw and low polydispersity (10–400 units), were synthesized to study the relationship between their chemical structure and biological effect.
Gáborjányi R, Almás M, Pál K, Tyihá E, Szökán Gy, Szende B, Khlafulla A R   +6 more
doaj   +1 more source

Anti-neoplastic action of Cimetidine/Vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer

Scientific Reports, 2022
The main focus of our study is to assess the anti-cancer activity of cimetidine and vitamin C via combating the tumor supportive role of mast cell mediators (histamine, VEGF, and TNF-α) within the tumor microenvironment and their effect on the protein ...
Sherihan Salaheldin Abdelhamid Ibrahim, Sarah A. Abd El-Aal, Ahmed M. Reda, Samar El Achy, Yasmine Shahine   +4 more
doaj   +1 more source