Results 21 to 30 of about 291,615 (215)
Disulfide Bond Formation in the Regulation of eIF-2 α Kinase by Heme [PDF]
Journal of Biological Chemistry, 1989 The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor (eIF)-2 alpha kinase (HRI) by hemin is very similar to that produced by thiol oxidation by diamide. The results obtained from the analysis of sodium dodecyl sulfate-polyacrylamide gel electrophoresis of unphosphorylated and phosphorylated HRI under reducing and
J J Chen +4 more
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Regulation of protein synthesis in eukaryotes by the protein kinases that phosphorylate initiation factor eIF‐2 [PDF]
FEBS Letters, 1980 Rajinder Singh Ranu
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Journal of Biological Chemistry, 1984 In heme-deficient reticulocyte lysates, protein synthesis initiation is inhibited due to the activation of a heme-regulated protein kinase which blocks protein synthesis by the specific phosphorylation of the alpha-sub-unit of eukaryotic initiation factor 2 (eIF-2 alpha).
A.M. Michelson +3 more
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Zhongguo shipin weisheng zazhi, 2023 ObjectiveTo study the cardioprotective effect of sesame ethanol extract （SEE） on exercise-induced fatigue （EIF） rats and its effects on myocardial physiological and biochemical parameters.MethodsRats were randomly divided into control group （Control ...
LI Qiang, MAO Yufeng
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Journal of Biological Chemistry, 1982 The kinetics of phosphorylation of eukaryotic initiation factor 2 (eIF-2) by two cyclic nucleotide-independent protein kinases from rabbit reticulocytes have been studied. The hemin-controlled repressor (HCR) and casein kinase II phosphorylate the alpha and beta subunits of eIF-2, respectively.
Mary Isabel Gonzatti, Jolinda A. Traugh
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The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition [PDF]
Diabetes & Metabolism Journal, 2011 Backgroundβ-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility has been suggested that sulfonylurea, currently being used as one of the main oral hypoglycemic ...
Min Jeong Kwon +10 more
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Curcumin: a bioactive compound with molecular targets for human malignancies
Food and Agricultural Immunology, 2023 Cancer is the second leading cause of death in the world and one of the major public health problems. Curcumin has anticancer activity including inducing apoptosis and inhibiting proliferation and invasion of tumours by suppressing a variety of cellular ...
Muhammad Shahbaz +12 more
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Journal of Biological Chemistry, 1993 A major mechanism of regulation of mammalian protein synthesis initiation is accomplished by the phosphorylation of the alpha subunit of eukaryotic initiation factor (eIF) 2. This modification inhibits the activity of another initiation factor, guanine nucleotide exchange factor, preventing conversion of eIF-2.GDP to eIF-2.GTP and hence binding of ...
Elizabeth A. Olmsted‐Davis +3 more
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Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. [PDF]
PLoS ONE, 2015 Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors.
Satoshi Koyama +7 more
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