Characterization and QTL Mapping of a Major Field Resistance Locus for Bacterial Blight in Rice
Plants, 2022 Bacterial blight (BB) disease, caused by Xanthomonas oryzae pv. oryzae (Xoo), is among the major factors that can cause rice yields to decrease. To address BB disease, researchers have been looking for ways to change pesticides and cultivation methods ...
Jae-Ryoung Park +6 more
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Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. [PDF]
Proceedings of the National Academy of Sciences, 1991 We have cloned the cDNA of the heme-regulated eIF-2 alpha kinase (HRI) of rabbit reticulocytes. In vitro translation of mRNA transcribed from the HRI cDNA yields a 90-kDa polypeptide that exhibits eIF-2 alpha kinase activity and is recognized by a monoclonal antibody directed against authentic HRI.
J J, Chen +6 more
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Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. [PDF]
Molecular and Cellular Biology, 1994 Previous studies have demonstrated that the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha), encoded by the SUI2 gene in the yeast Saccharomyces cerevisiae, is phosphorylated at Ser-51 by the GCN2 kinase in response to general amino acid control.
L, Feng, H, Yoon, T F, Donahue
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Topical losartan as a novel therapeutic approach for corneal scars: clinical outcomes from a case series [PDF]
Revista Brasileira de OftalmologiaThe objective was to investigate the efficacy of topical losartan in treating corneal scars in patients with varying clinical backgrounds. A case series with six patients diagnosed with corneal scars resulting from herpetic keratitis or complicated ...
Gonçalo Cavaco Tardão +7 more
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Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2 [PDF]
Journal of Biological Chemistry, 1996 In yeast, starvation for amino acids stimulates GCN2 phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2). Phosphorylation of eIF-2alpha induces the translational expression of GCN4, a transcriptional activator of the general amino acid control pathway.
S, Zhu, A Y, Sobolev, R C, Wek
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Effects of Dietary Crude Protein Levels and Cysteamine Supplementation on Protein Synthetic and Degradative Signaling in Skeletal Muscle of Finishing Pigs. [PDF]
PLoS ONE, 2015 Dietary protein levels and cysteamine (CS) supplementation can affect growth performance and protein metabolism of pigs. However, the influence of dietary protein intake on the growth response of CS-treated pigs is unclear, and the mechanisms involved in
Ping Zhou +9 more
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Erythroid Expression of the Heme-Regulated eIF-2α Kinase [PDF]
Molecular and Cellular Biology, 1994 The role of heme-regulated eIF-2 alpha kinase (HRI) in the regulation of protein synthesis in rabbit reticulocytes is well documented. Inhibitors of protein synthesis with properties similar to those of HRI have been described in some nonerythroid cell types, but it has not yet been determined whether these eIF-2 alpha kinase activities are mediated by
J S, Crosby +3 more
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Disulfide Bond Formation in the Regulation of eIF-2 α Kinase by Heme
Journal of Biological Chemistry, 1989 Abstract The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor (eIF)-2 alpha kinase (HRI) by hemin is very similar to that produced by thiol oxidation by diamide. The results obtained from the analysis of sodium dodecyl sulfate-polyacrylamide gel electrophoresis of unphosphorylated and phosphorylated HRI under ...
J J Chen +4 more
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International Journal of Inflammation, 2014 The intensities of macrophage inflammatory responses to bacterial components gradually decrease with age. Given that a reduced rate of protein synthesis is a common age-related biochemical change, which is partially mediated by increased phosphorylation ...
Ken Shirato, Kazuhiko Imaizumi
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Journal of Animal Science and Biotechnology, 2012 Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine's action in vivo is not well understood. In
Suryawan Agus +3 more
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