Results 21 to 30 of about 15,971 (150)

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus

Journal of Immunology Research, 2015
Previous studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) from patients with systemic lupus erythematosus (SLE) exhibited the phenomenon of apoptosis.
Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu   +6 more
doaj   +1 more source

Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissues⃞

Journal of Lipid Research, 2008
Obesity and insulin resistance are independent risk factors for metabolic syndrome, diabetes, and cardiovascular disease. Adipose tissue samples from nonobese (NO), insulin-sensitive obese (ISO), and insulin-resistant obese (IRO) subjects from ...
R. MacLaren, W. Cui, S. Simard, K. Cianflone   +3 more
doaj   +1 more source

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

PLoS ONE, 2011
BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter.
Gerard Ill-Raga, Ernest Palomer, Matthew A Wozniak, Eva Ramos-Fernández, Mònica Bosch-Morató, Marta Tajes, Francesc X Guix, José J Galán, Jordi Clarimón, Carmen Antúnez, Luis M Real, Mercé Boada, Ruth F Itzhaki, César Fandos, Francisco J Muñoz   +14 more
doaj   +1 more source

Phospholipid‐sensitive Ca²⁺‐dependent protein kinase phosphorylates the β subunit of eukaryotic initiation factor 2 (eIF‐2) [PDF]

FEBS Letters, 1983
The ability of homogeneous phospholipid‐sensitive Ca2+‐dependent protein kinase (PL‐Ca‐PK) from pig spleen to phosphorylate eukaryotic initiation factor 2 (eIF‐2) was examined. PL‐Ca‐PK phosphorylated the β‐subunit of eIF‐2, whereas myosin light chain kinase (MLCK) and cyclic AMP‐ and cyclic GMP‐dependent protein kinases (cA‐PK and cG‐PK) did not.
Schatzman, Randall C., Grifo, Jamie A., Merrick, William C., Kuo, J.F.   +3 more
openaire   +2 more sources

Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells

Journal of Biological Chemistry, 1993
A major mechanism of regulation of mammalian protein synthesis initiation is accomplished by the phosphorylation of the alpha subunit of eukaryotic initiation factor (eIF) 2. This modification inhibits the activity of another initiation factor, guanine nucleotide exchange factor, preventing conversion of eIF-2.GDP to eIF-2.GTP and hence binding of ...
E A, Olmsted, L, O'Brien, E C, Henshaw, R, Panniers   +3 more
openaire   +2 more sources

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Genomic characterization of plant height and lodging in spring oat (Avena sativa L.) using time‐series aerial sensor data

The Plant Phenome Journal, Volume 9, Issue 1, December 2026.
Abstract Plant height is one of the key economic traits in spring oat (Avena sativa L.) and a major determinant of lodging, and consequently, yield potential. Understanding the genetic basis of the variation in plant height can significantly benefit plant improvement efforts.
Afrina Rahman, Anup Kumar Das, Jayanta Roy, Amandeep, Michael S. McMullen, Paulo Flores, Craig H. Carlson   +6 more
wiley   +1 more source

Conformational ensembles of the disordered 4E‐BP2:eIF4E complex restrained by smFRET experiments

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Eukaryotic cap‐dependent translation initiation is regulated by binding of the predominantly folded eukaryotic initiation factor 4E (eIF4E) to the intrinsically disordered eIF4E binding proteins (4E‐BPs). Here, we report full‐length atomistic conformational ensembles generated by IDPConformerGenerator and optimized by X‐EISDv2 workflow for ...
Spencer Smyth, Zi Hao Liu, Thomas E. Tsangaris, Teresa Head‐Gordon, Julie D. Forman‐Kay, Claudiu C. Gradinaru   +5 more
wiley   +1 more source

PKR associates with 4.1R to promote anchorage-independent growth of hepatocellular carcinoma and lead to poor prognosis

Scientific Reports
RNA-dependent protein kinase (PKR) may have a positive regulatory role in controlling tumor growth and progression in hepatocellular carcinoma (HCC). However, the downstream substrates and the molecular mechanism of PKR in the growth and progression of ...
Yusuke Okujima, Takao Watanabe, Takeshi Ito, Yasumichi Inoue, Yutaka Kasai, Yusuke Imai, Yoshiko Nakamura, Mitsuhito Koizumi, Osamu Yoshida, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Ryosuke Kawakami, Takashi Saitou, Takeshi Imamura, Yoshinori Murakami, Yoichi Hiasa   +16 more
doaj   +1 more source

Presence of haemin-controlled eIF-2α kinases in both undifferentiated and differentiating mouse erythroleukaemia cells [PDF]

Biochemical Journal, 1989
In rabbit reticulocytes, globin synthesis is regulated by a haemin-controlled translational inhibitor (HCI) which acts by phosphorylating the alpha-subunit of eukaryotic initiation factor 2 (eIF-2). With purified eIF-2 as substrate, haemin-controlled eIF-2 alpha kinases could be partially purified from cultured mouse erythroleukaemia cells (MEL cells),
openaire   +2 more sources