Results 41 to 50 of about 291,615 (215)

Phosphorylation stoichiometries of human eukaryotic initiation factors. [PDF]

, 2014
Eukaryotic translation initiation factors are the principal molecular effectors regulating the process converting nucleic acid to functional protein. Commonly referred to as eIFs (eukaryotic initiation factors), this suite of proteins is comprised of at ...
Andaya, Armann, Fraser, Christopher S, Jia, Weitao, Leary, Julie A, Villa, Nancy   +4 more
core   +2 more sources

Posttranscriptional Suppression of Lipopolysaccharide-Stimulated Inflammatory Responses by Macrophages in Middle-Aged Mice: A Possible Role for Eukaryotic Initiation Factor 2α

International Journal of Inflammation, 2014
The intensities of macrophage inflammatory responses to bacterial components gradually decrease with age. Given that a reduced rate of protein synthesis is a common age-related biochemical change, which is partially mediated by increased phosphorylation ...
Ken Shirato, Kazuhiko Imaizumi
doaj   +1 more source

Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs [PDF]

, 2003
Double-stranded RNA (dsRNA) is a by-product of viral RNA polymerase activity, and its recognition is one mechanism by which the innate immune system is activated.
Boyd, Amanda, Bridgen, Anne, Elliott, Richard M, Fazakerley, John K, Streitenfeld, Hein, Weber, Friedemann   +5 more
core   +3 more sources

Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway

Journal of Animal Science and Biotechnology, 2012
Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine's action in vivo is not well understood. In
Suryawan Agus, Nguyen Hanh V, Almonaci Rosemarie D, Davis Teresa A   +3 more
doaj   +1 more source

Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa [PDF]

, 2006
The causative molecular pathways underlying the pathogenesis of colorectal cancer (CRC) need to be better characterized. The purpose of our study was to better understand the genetic mechanism of oncogenesis for human colorectal cancer and to identify ...
Bianchini, Michele, Carinci, Paolo, De Sanctis, Paola, Levy, Estrella Mariel, Macagno, Carlo, Mordoh, Jose, Pinski, Victor, Valvassori, Luisa, Zucchini, Cinzia   +8 more
core   +1 more source

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythematosus

Journal of Immunology Research, 2015
Previous studies indicated that bone marrow mesenchymal stem cells (BM-MSCs) from patients with systemic lupus erythematosus (SLE) exhibited the phenomenon of apoptosis.
Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu   +6 more
doaj   +1 more source

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.

Journal of Biological Chemistry, 1994
Reticulocytes contain an eukaryotic initiation factor-2 alpha (eIF-2 alpha) kinase that is negatively regulated by hemin. This protein kinase, which has been termed heme-regulated inhibitor and heme-controlled repressor (HCR), has a strong inhibitory effect on the initiation of protein synthesis and plays an important role in translational control in ...
Harry Mellor, Kevin M. Flowers, Scot R. Kimball, Leonard S. Jefferson   +3 more
openalex   +4 more sources

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. [PDF]

, 2015
Previously, we identified ISRIB as a potent inhibitor of the integrated stress response (ISR) and showed that ISRIB makes cells resistant to the effects of eIF2α phosphorylation and enhances long-term memory in rodents (Sidrauski et al., 2013).
Ingolia, Nicholas T, McGeachy, Anna M, Sidrauski, Carmela, Walter, Peter   +3 more
core   +2 more sources

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.

PLoS ONE, 2011
BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter.
Gerard Ill-Raga, Ernest Palomer, Matthew A Wozniak, Eva Ramos-Fernández, Mònica Bosch-Morató, Marta Tajes, Francesc X Guix, José J Galán, Jordi Clarimón, Carmen Antúnez, Luis M Real, Mercé Boada, Ruth F Itzhaki, César Fandos, Francisco J Muñoz   +14 more
doaj   +1 more source