Results 51 to 60 of about 15,971 (150)

Identification of Distinct Interacting Proteins of Giardia lamblia Centrins Using Yeast Two‐Hybrid Assays

Journal of Eukaryotic Microbiology, Volume 73, Issue 4, July/August 2026.
ABSTRACT Giardia lamblia, a protozoan parasite that causes diarrhea in humans, contains two centrins implicated in cellular morphology and cell division. To identify proteins interacting with each G. lamblia centrin (GlCent), we performed a yeast two‐hybrid assay.
Mee Young Shin, Juri Kim, Soon‐Jung Park   +2 more
wiley   +1 more source

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta‐Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Understanding the congruent effects of different types of antidepressant treatments on sensitive brain regions, such as the hippocampus and cortex, can highlight essential mechanisms of action. We used a systematic meta‐analysis of public transcriptional profiling datasets to identify genes and functional gene sets that are differentially expressed ...
Eva M. Geoghegan, Megan H. Hagenauer, Erin Hernandez, Sophia Espinoza, Elizabeth I. Flandreau, Phi T. Nguyen, Adrienne N. Santiago, Mubashshir Ra’eed Bhuiyan, Sophie Mensch, Stanley J. Watson Jr., Huda Akil, René Hen   +11 more
wiley   +1 more source

Rapid CO2 effects on protein‐related metabolism during photosynthetic gas exchange

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY It is common practice to vary atmospheric CO2 mole fraction (Ca) during gas exchange experiments to manipulate photorespiration and explore photosynthetic properties such as maximum carboxylation velocity. In doing so, it is assumed that changing Ca essentially alters the carboxylation‐to‐oxygenation ratio, with negligible effects on other ...
Corentin Dourmap, Cyril Abadie, Marlène Davanture, Willy Bienvenut, Julie Lalande, Guillaume Tcherkez   +5 more
wiley   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Kinetics of Phosphorylation of eIF-2 by the hemin-controlled repressor and casein kinase II. Inhibition by hemin and 2,3-diphosphoglyceric acid.

Journal of Biological Chemistry, 1982
The kinetics of phosphorylation of eukaryotic initiation factor 2 (eIF-2) by two cyclic nucleotide-independent protein kinases from rabbit reticulocytes have been studied. The hemin-controlled repressor (HCR) and casein kinase II phosphorylate the alpha and beta subunits of eIF-2, respectively.
, Gonzatti-Haces MIrn, J A, Traugh
openaire   +2 more sources

Hsp90 mediates activation of the heme regulated eIF-2 alpha kinase during oxidative stress.

Indian journal of biochemistry & biophysics, 2010
The heme-regulated inhibitor (HRI), a member of the eIF-2 alpha kinase family is crucial for regulating protein synthesis during stress. In addition to heme, stress proteins Hsp90 and Hsp70 are known to regulate HRI. The present study aims to determine the physical association of these Hsps in the regulation of HRI activation during oxidative stress ...
A P, Kulkarni, S P, Mittal, T P A, Devasagayam, J K, Pal   +3 more
openaire   +1 more source

Effects of glucose 6-phosphate and hemin on activation of heme-regulated eIF-2 alpha kinase in gel-filtered reticulocyte lysates.

Journal of Biological Chemistry, 1984
In heme-deficient reticulocyte lysates, protein synthesis initiation is inhibited due to the activation of a heme-regulated protein kinase which blocks protein synthesis by the specific phosphorylation of the alpha-sub-unit of eukaryotic initiation factor 2 (eIF-2 alpha).
A M, Michelson, V, Ernst, D H, Levin, I M, London   +3 more
openaire   +2 more sources

Regulation of protein synthesis in rabbit reticulocyte lysates [PDF]

FEBS Letters, 1986
The heme‐regulated protein kinase, which specifically phosphorylates the 38‐kDa subunit of initiation factor eiF‐2, can utilize adenosine 5′‐O‐(3‐thiotriphosphate) (ATP[γS]) as a substrate. The rate of thiophosphorylation is 5‐6‐times slower than that observed with ATP.
openaire   +2 more sources

Effects of fermented soybean meal replacing fish meal protein on growth performance， antioxidant function， and mTOR signaling pathway of Litopaeneaus vannamei

Siliao yanjiu
The experiment aimed to investigate the effects of fermented soybean meal replacing fish meal protein on the growth performance, antioxidant function, and rapamycin target protein (mTOR) signaling pathway of Litopenaeus vannamei.
LIN Nan, LI Zhangqi, ZHENG Qingyin, WU Liwen, SHAO Jianchun, WANG Xuexi   +5 more
doaj