Exploring the Potential and Advancements of Circular RNA Therapeutics
Exploration, Volume 5, Issue 4, August 2025.Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang +6 more
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RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications
MedComm, Volume 6, Issue 8, August 2025.RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang +4 more
wiley +1 more source
Regulation of protein synthesis in rabbit reticulocyte lysates [PDF]
FEBS Letters, 1986 The heme‐regulated protein kinase, which specifically phosphorylates the 38‐kDa subunit of initiation factor eiF‐2, can utilize adenosine 5′‐O‐(3‐thiotriphosphate) (ATP[γS]) as a substrate. The rate of thiophosphorylation is 5‐6‐times slower than that observed with ATP.
openaire +2 more sources
Anti-Growth, Anti-Angiogenic, and Pro-Apoptotic Effects by CX-4945, an Inhibitor of Casein Kinase 2, on HuCCT-1 Human Cholangiocarcinoma Cells via Control of Caspase-9/3, DR-4, STAT-3/STAT-5, Mcl-1, eIF-2α, and HIF-1α [PDF]
, 2022 Saini Wang +4 more
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Changes in the phosphorylation of initiation factor eIF‐2α, elongation factor eEF‐2 and p70 S6 kinase after transient focal cerebral ischaemia in mice [PDF]
, 2001 Sonja Althausen +6 more
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Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. [PDF]
, 1994 Carlos R. Vázquez de Aldana +4 more
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