Results 121 to 130 of about 14,373,368 (289)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Development of the cultural tailoring score (CTS): a scoring instrument to assess cultural tailoring of health messaging

Health Literacy and Communication Open
Background Cultural tailoring of health information has been associated with better health outcomes in minority populations. While contractors and partner organizations are asked to produce culturally appropriate materials, there are no government ...
Claudia Parvanta, Kayleigh Murray, Samantha Boddupalli, Natalie Erasme, Rheese McNab, Vijay Prajapati, Arabel Severe, Aura Reyes, Richard Harner, Rhonda Holliday   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using the Elaboration Likelihood Model to Identify the Optimum Facebook Video Marketing Strategy for Travel Agencies

SAGE Open
This paper examines the impact of travel agencies’ video marketing campaigns on their marketing efficiency and effectiveness on Facebook (FB), with a focus on analyzing the characteristics of these campaigns.
Chin-Yi Fang, Ya-Ping Chang, Tai-Ning Yang, Ying-Chen Lo   +3 more
doaj   +1 more source

From Traffic to Quality: A Study on the Dual-Path Driving Effects of Streamer Traits on Consumer Trust and Identification

Journal of Theoretical and Applied Electronic Commerce Research
This study is based on the practical context of the livestream e-commerce industry’s shift from “traffic competition” to “quality competition”. Addressing the limitations of existing research that predominantly focuses on streamers’ external traits while
Ru Wang, Shugang Li, Liqin Zhang
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Persuasion Over Time: A Longitudinal Analysis of Message Strategy and Engagement in B2B Instagram using ELM

Habitat
The rise of mobile-first platforms has transformed how Business-to-Business (B2B) communication operates, including the persuasive mechanisms involved.
Meita Dinar Astaningrum, Reza Safitri, Fitri Hariana Oktaviani   +2 more
doaj   +1 more source

Elaboration Likelihood Model : Kisah Perjalanan Sebuah Ilmu (Studi Filsafat Ilmu Komunikasi Dengan Metode Meta Analisis Studi Elaboration Likelihood Model (ELM) Di Fakultas Ilmu Sosial dan Ilmu Politik Universitas Brawijaya Tahun 2013-2016) [PDF]

, 2017
Elaboration Likelihood Model (ELM) merupakan teori yang digunakan untuk mengkaji komunikasi persuasif. Teori ini untuk pertama kalinya dikembangkan oleh Petty dan Cacioppo pada tahun 1980.
Amrullah,, Nuzul
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Deciphering the persuasive power of information overload in live commerce: A tactics approach to consumer decision-making

Acta Psychologica
In the context of the growing prevalence of live commerce, live sellers face an increasing challenge in convincing consumers to form purchase intentions and move closer to completing their purchases, prompting them to develop innovative marketing tactics.
Junwei Cao, Lingling Zhong, Guihua Zhang, Dong Liu, Yaolong Lyu, Xian Qiu   +5 more
doaj   +1 more source