Results 261 to 270 of about 87,970 (343)

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Synergistic and Antagonistic Mechanisms of <i>Arctium lappa</i> L. Polyphenols on Human Neutrophil Elastase Inhibition: Insights from Molecular Docking and Enzymatic Kinetics. [PDF]

Molecules
Sun Y, Zhang M, Zhang Y, Zheng Y, Li J, Cai Q, Wang A, Qu Y.   +7 more
europepmc   +1 more source

Modulating Antimicrobial Activity and Structure of the Peptide Esc(1‐21) via Site‐Specific Isopeptide Bond Formation

Journal of Peptide Science, Volume 31, Issue 9, September 2025.
The introduction of an isopeptide bond at the lysine residues in the backbone of Esc(1‐21) led to the generation of five analogs. Among these, Esc(1‐21)ε20 showed the most promising features, having antimicrobial activity comparable with those of the parent peptide, a lower cytotoxicity, and a higher stability to proteolytic degradation.
Bruno Casciaro, Daniel Ben Hur, Daniela Roversi, Carlo Vetrano, Edo Kiper, Giacomo Cappella, Federico Carneri, Eeva Tortellini, Lorenzo Stella, Neta Regev‐Rudzki, Yechiel Shai, Maria Luisa Mangoni   +11 more
wiley   +1 more source

<i>In vitro</i> and <i>in vivo</i> anti-<i>Pseudomonas aeruginosa</i> activity of a scorpion peptide derivative. [PDF]

Front Microbiol
Li Z, Zhang J, Liu Y, Dai Q, Li S, Deng B, Wu P, Li W, Dong Y, Xin P, Zhang W.   +10 more
europepmc   +1 more source

Processing‐Driven Changes in Potato Protein‐Stabilized Emulsions and Their Digestibility: The Role of High‐Pressure Homogenization and Thermal Treatment

Sustainable Food Proteins, Volume 3, Issue 3, September 2025.
Process flow and summary of the experimental setup used to assess in vitro proteolysis and lipolysis of emulsions processed through high‐pressure homogenization and/or heat treatment. ABSTRACT This study investigates the digestibility of emulsions stabilized with potato protein isolate, focusing on how different processing conditions affect their ...
Luis Jiménez‐Munoz, Kamelia Stark, Milena Corredig   +2 more
wiley   +1 more source

Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility. [PDF]

Endocr Connect
Das M, Gumssani M, Mullaney J, Henkel R, Minhas S, Aquilina MC, Jayasena CN.   +6 more
europepmc   +1 more source

Role of PMN elastase on ischemic myocardial injury in evolving myocardial infarction: Correlation with clinical parameters and intervention by protease inhibitor ulinastatin.

, 1989
Shinichiro Shimai, Teruo Takano, Yoshihiko Seino, Keiji Tanaka, Hirokazu Hayakawa   +4 more
openalex   +2 more sources

Quantum Chemical, Spectroscopic and In Silico (Molecular Docking, Molecular Dynamic and ADME) Studies on Anti‐Aging Pentapeptide‐3 (Vialox)

International Journal of Quantum Chemistry, Volume 125, Issue 15, August 5, 2025.
This study investigates the anti‐aging potential of Pentapeptide‐3 (Vialox) using quantum chemical, spectroscopic, and in silico methods. Molecular docking and dynamics analysis confirm its stable interactions with key aging‐related receptors, highlighting Pentapeptide‐3 as a promising candidate for cosmeceutical applications targeting skin aging ...
Dilan Akhan, Bilge Bicak, Serda Kecel Gunduz, Elif Akalin   +3 more
wiley   +1 more source

Solvent Fractionation of <i>Polygonum cuspidatum</i> Sieb. et Zucc. for Antioxidant, Biological Activity, and Chromatographic Characterization. [PDF]

Int J Mol Sci
Cheng Y, Kang Y, Kim W.
europepmc   +1 more source