Results 271 to 280 of about 87,970 (343)

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, Volume 91, Issue 8, Page 2262-2272, August 2025.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease. [PDF]

World J Gastroenterol
Feješ A, Belvončíková P, Bečka E, Strečanský T, Pastorek M, Janko J, Filová B, Babál P, Šebeková K, Borbélyová V, Gardlík R.   +10 more
europepmc   +1 more source

Pulmonary Artery Aneurysm (PAA) in Behçet's Disease Presenting With Recurrent Hemoptysis: A Case Report

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT Pulmonary artery aneurysm is a serious but under‐recognized complication of Behçet's disease that may present with hemoptysis. Early diagnosis coupled with timely initiation of immunosuppressive therapy is crucial in preventing aneurysmal progression and associated life‐threatening complications.
Shahabaldin Sorouri, Maryam Safari Farmad, Amirhossein Amiriani, Amir Baniasad   +3 more
wiley   +1 more source

Measuring artery diameter in rabbit angiograms for neurovascular disease modeling applications and device testing.

Interv Neuroradiol
Khan Y, Franklin J, Cortese J, Bayraktar EA, Oliver AA, Ding YH, Lortscher S, Brinjikji W, Kadirvel R, Kallmes DF.   +9 more
europepmc   +1 more source

Evaluation of Cystic Fibrosis Newborn Screening and Follow-Up Process in Georgia (2022-2023). [PDF]

Int J Neonatal Screen
Vardosanidze N, Kavlashvili N, Margvelashvili L, Kvlividze O, Diakonidze M, Iordanishvili S, Agladze D.   +6 more
europepmc   +1 more source

Genetic and Environmental Contributions to Serological Biomarkers of Extracellular Matrix Remodeling in Asthma: A Twin Study

Clinical and Translational Allergy, Volume 15, Issue 8, August 2025.
ABSTRACT Background Asthma is characterized by airway obstruction driven by chronic inflammation, leading to extracellular matrix (ECM) remodeling. This involves ECM alterations, including increased collagen deposition and elastolysis, resulting in airway wall thickening and irreversible airflow limitation. Despite ECM remodeling's known role in asthma,
Matej Andelic, Vibeke Backer, Kirsten Ohm Kyvik, Signe Holm Nielsen, Simon Francis Thomsen   +4 more
wiley   +1 more source

Plant-Based Potential in Diabetes Management: In Vitro Antioxidant, Wound-Healing, and Enzyme Inhibitory Activities of Southern Algarve Species. [PDF]

Molecules
Carvalho IS, Viegas C, Markiewicz M, Galanty A, Paśko P, Jakupović L, Končić MZ.   +6 more
europepmc   +1 more source

Development of a protease-resistant ADAMTS13 to improve stability against proteolytic degradation. [PDF]

Blood Adv
DeYoung V, Huang R, Madarati H, Malik R, Andrisani P, Teney C, Kretz CA.   +6 more
europepmc   +1 more source

Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Eugenol (Eug), a volatile phenolic bioactive compound with formula of C10H12O2 have been reported with anticancer, antidiabetic, cardio‐ and pulmonary protective role. Moreover, it has the ability to improve gut health and prevent neurodegenerative disorders. According to WHO, the safe dose of Eug is 2.5 mg/kg for consumption.
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Waqas Ahmad Khan, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Entessar Al Jbawi, Suliman A. Alsagaby, Waleed Al Abdulmonem   +13 more
wiley   +1 more source

"Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles" Mechanistic Insights into Cancer Protection Through Signaling Modulation and Lymphangiogenesis Control. [PDF]

Cells
Muzzin S, Timis E, Doliana R, Mongiat M, Spessotto P.   +4 more
europepmc   +1 more source