Results 231 to 240 of about 86,123 (343)

Mechanopharmacology of cellular microenvironment stiffness: Therapeutic strategies for age‐related diseases

British Journal of Pharmacology, EarlyView.
Ageing brings about various biochemical, structural and mechanical alterations within tissues, profoundly impacting cellular behaviour and function. One of the hallmark changes observed with ageing is an increase in cellular microenvironment stiffness, a biomechanical property influenced by intrinsic factors within the cell and extrinsic factors from ...
Wang HaiYang, Cheong Dorothy Hui Juan, Lee Zhao‐Yong, Tran Thai   +3 more
wiley   +1 more source

Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK

Antioxidants and Redox Signaling, 2017
Sonia Martínez-Revelles, A. García-Redondo, M. Avendaño, S. Varona, T. Palao, M. Orriols, F. Roque, A. Fortuño, R. Touyz, J. Martínez-González, M. Salaices, C. Rodríguez, A. Briones   +12 more
semanticscholar   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Elastin-like recombinamers in collagen-based tubular gels improve cell-mediated remodeling and viscoelastic properties

, 2020
Dimitria Bonizol Camasão, Miguel González‐Pérez, Sara Palladino, Matilde Alonso, José Carlos Rodríguez‐Cabello, Diego Mantovani   +5 more
openalex   +2 more sources

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Acne tarda: Recommendations for classification, treatment and care as a result of an expert discussion

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Acne tarda is defined in the literature as adult acne, which according to most authors occurs in women aged 25 and older. However, the definitions and age groups vary depending on the study. Current guidelines rarely address adult acne. In this review, current studies and the literature on acne tarda are analyzed and evaluated by German experts.
Matthias Augustin, Thomas Dirschka, Peter Arne Gerber, Martina Kerscher, Natalia Kirsten, Falk Ochsendorf   +5 more
wiley   +1 more source

C106 Multiphoton microscopy for 3D microstructure of elastin and collagen fibers in the aortic media

, 2014
Shukei Sugita, Takeo MATSUMOTΟ
openalex   +1 more source

Identification of a soluble intermediate during synthesis of elastin by embryonic chick aortae [PDF]

, 1972
Lois Murphy, Margaret Harsch, Tomohiko Mori, Joel Rosenbloom   +3 more
openalex   +1 more source

Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome

Journal of Pathology, 2017
S. Wanga, S. Hibender, Y. Ridwan, C. V. van Roomen, M. Vos, I. van der Made, N. van Vliet, R. Franken, Luigi van Riel, M. Groenink, A. Zwinderman, B. Mulder, C. D. de Vries, J. Essers, V. de Waard   +14 more
semanticscholar   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, EarlyView.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source