Results 1 to 10 of about 3,973 (127)

Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks

Biomolecules, 2021
Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Suzanne M Mithieux, Anthony S Weiss, Weiss Anthony S   +2 more
exaly   +3 more sources

Biomolecular Changes Upon Ablative Laser Therapy of the Skin: A Scoping Review. [PDF]

Int J Dermatol
(Fractional) ablative laser therapy results in a wound healing response characterized by an inflammatory phase, dermal matrix degradation, and remodeling, collagenesis and elastogenesis. This is characterized by an increase in metalloproteinases, collagen type I, III, VII, and tropoelastin.
Debeuf MPH, Rauwenhoff MHP, van Geel M, Steijlen PM, Verstraeten VLRM.   +4 more
europepmc   +2 more sources

Tropoelastin and Elastin Assembly

Frontiers in Bioengineering and Biotechnology, 2021
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues.
Chengeng Yang, Stuart A Cain, Clair Baldock   +2 more
exaly   +3 more sources

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts. [PDF]

Adv Sci (Weinh)
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Chen M, Chilkoti A.
europepmc   +2 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]

Advanced Science
Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
doaj   +2 more sources

Evolutionary constraints on positional sequence, collective properties and sequence style of tropoelastin dictated by fundamental requirements for formation and function of the extracellular elastic matrix [PDF]

Matrix Biology Plus
Elastin is the extracellular matrix protein responsible for properties of extension and energy-efficient elastic recoil in large blood vessels, lung parenchyma and other vertebrate tissues.
Fred W. Keeley
doaj   +2 more sources

TriHex Technology and Reversal of Solar Elastosis: Dispelling Some Myths. [PDF]

J Cosmet Dermatol
ABSTRACT Background Solar elastosis (SE) is the end result of long‐term sun damage, characterized by a buildup of dystrophic material in the extracellular matrix (ECM) surrounded by fragmented collagen and dysfunctional, aggregated elastin. This degenerative process was once thought to be irreversible but is now recognized as dynamic, with the ...
Widgerow AD, Napekoski K, Shafiq F, Robison T.   +3 more
europepmc   +2 more sources

Mechanically Induced Skin Renewal: Evidence-Based Insights Into Clinical, Structural and Inflammatory Changes Activated by Microneedling, Microdermabrasion and Microvibration. [PDF]

J Cosmet Dermatol
ABSTRACT Background Device‐based aesthetic procedures such as microneedling, microdermabrasion and microvibration have gained widespread clinical and institutional use for skin rejuvenation, yet the underlying biological mechanisms and the robustness of clinical evidence remain incompletely established.
Springer A, Helfenbein E, Blaak J.
europepmc   +2 more sources

Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly [PDF]

Redox Report
Background Tropoelastin (TE), the soluble precursor of elastin, is critical for the elasticity of arteries, lungs, and skin. Oxidative damage to TE has been implicated in vascular diseases, but the isoform-specific effects remain poorly understood ...
Karoline Lindgaard Mikkelsen, Tina Nybo, Michael J. Davies, Adelina Rogowska-Wrzesinska   +3 more
doaj   +2 more sources

Radical-Mediated, Substrate-Independent Fabrication of Hybrid Solid-Hydrogel Materials With Tunable Crosslinking: An Initiator- and Crosslinker-Free Approach. [PDF]

Adv Sci (Weinh)
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Shineh G, Khodaei A, Keikhosravani P, Zhianmanesh M, Xia Y, Gilmour A, Naficy S, Guzina A, Bianchi D, Lim KS, Dehghani F, Yavari SA, Bilek M, Yeo GC, Akhavan B.   +14 more
europepmc   +2 more sources