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Tropoelastin and Elastin Assembly [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues.
Chengeng Yang, Stuart A Cain, Clair Baldock   +2 more
exaly   +6 more sources

Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 [PDF]

Biomolecules, 2020
Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A. Boyle, Marie-Paule Jacob, Gilles Faury   +7 more
doaj   +4 more sources

Tropoelastin Improves Post-Infarct Cardiac Function [PDF]

Circulation Research, 2023
Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may have more favorable properties within the cardiac scar.
Robert Hume, Shaan Kanagalingam, Tejas Deshmukh   +2 more
exaly   +4 more sources

Stochastic simulations of self-organized elastogenesis in the developing lung. [PDF]

PLoS Computational Biology, 2023
In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan, Cristian Valenzuela, Weijing Zhao, Zi Chen, Dong Wang, Steven J Mentzer   +5 more
doaj   +2 more sources

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]

Advanced Science
Cellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee, Aleen Al Halawani, Jonathan D. Teo, Anthony S. Weiss, Giselle C. Yeo   +4 more
doaj   +2 more sources

Evolutionary constraints on positional sequence, collective properties and sequence style of tropoelastin dictated by fundamental requirements for formation and function of the extracellular elastic matrix [PDF]

Matrix Biology Plus
Elastin is the extracellular matrix protein responsible for properties of extension and energy-efficient elastic recoil in large blood vessels, lung parenchyma and other vertebrate tissues.
Fred W. Keeley
doaj   +2 more sources

Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly [PDF]

Redox Report
Background Tropoelastin (TE), the soluble precursor of elastin, is critical for the elasticity of arteries, lungs, and skin. Oxidative damage to TE has been implicated in vascular diseases, but the isoform-specific effects remain poorly understood ...
Karoline Lindgaard Mikkelsen, Tina Nybo, Michael J. Davies, Adelina Rogowska-Wrzesinska   +3 more
doaj   +2 more sources

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
doaj   +2 more sources

Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks

Biomolecules, 2021
Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Aleen Al Halawani, Lea Abdulkhalek, Suzanne M. Mithieux, Anthony S. Weiss   +3 more
doaj   +1 more source

Fibrous Scaffolds From Elastin-Based Materials

Frontiers in Bioengineering and Biotechnology, 2021
Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to
Jose Carlos Rodriguez-Cabello, Jose Carlos Rodriguez-Cabello, Israel Gonzalez De Torre, Israel Gonzalez De Torre, Miguel González-Pérez, Miguel González-Pérez, Fernando González-Pérez, Fernando González-Pérez, Irene Montequi, Irene Montequi   +9 more
doaj   +1 more source