Results 21 to 30 of about 4,779 (198)

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures
Elastin‐like polypeptides (ELPs), genetically programmable biomaterials derived from natural tropoelastin, exhibit unique reversible self‐assembly and aggregation behaviors driven by sequence‐encoded phase transitions.
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
doaj   +2 more sources

Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]

Nature Communications
Microfibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny, Valentin Nelea, Iram Fatima S. Siddiqui, Shaynah Wanga, Vivian de Waard, Mike Strauss, Dieter P. Reinhardt   +6 more
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Biochemistry of tropoelastin [PDF]

European Journal of Biochemistry, 1998
Elastic fibres are an important component of the extracellular matrix and are made of two major components : the more abundant cross‐linked elastic protein elastin and the multi‐component microfibrils. The biosynthesis of elastic fibres is a complex process involving the interplay of many diverse proteins and genes with elastin as the major component ...
B, Vrhovski, A S, Weiss
openaire   +2 more sources

Stochastic simulations of self-organized elastogenesis in the developing lung.

PLoS Computational Biology, 2023
In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan, Cristian Valenzuela, Weijing Zhao, Zi Chen, Dong Wang, Steven J Mentzer   +5 more
doaj   +1 more source

Fibrous Scaffolds From Elastin-Based Materials

Frontiers in Bioengineering and Biotechnology, 2021
Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to
Jose Carlos Rodriguez-Cabello, Jose Carlos Rodriguez-Cabello, Israel Gonzalez De Torre, Israel Gonzalez De Torre, Miguel González-Pérez, Miguel González-Pérez, Fernando González-Pérez, Fernando González-Pérez, Irene Montequi, Irene Montequi   +9 more
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Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. [PDF]

PLoS ONE, 2017
Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix components ...
Stephanie E Seidl, Lawrence G Pessolano, Christopher A Bishop, Michael Best, Celeste B Rich, Phillip J Stone, Barbara M Schreiber   +6 more
doaj   +1 more source

Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

Frontiers in Materials, 2021
Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi, Lubinda Mbundi, Miguel González-Pérez, Fernando González-Pérez, Diana Juanes-Gusano, José Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source

Tropoelastin-Pretreated Exosomes from Adipose-Derived Stem Cells Improve the Synthesis of Cartilage Matrix and Alleviate Osteoarthritis

Journal of Functional Biomaterials, 2023
Mesenchymal stem cells (MSCs) have recently been widely used to treat osteoarthritis (OA). Our prior research shows that tropoelastin (TE) increases MSC activity and protects knee cartilage from OA-related degradation.
Shuo Meng, Cong Tang, Muhai Deng, Jie Yuan, Yanli Fan, Shasha Gao, Yong Feng, Junjun Yang, Cheng Chen   +8 more
doaj   +1 more source

Radioimmunological identification of tropoelastin [PDF]

Biochemical Journal, 1976
Antiserum was prepared in sheep against insoluble elastin isolated from embryonic-chick aortae. In an indirect immunoprecipitation test, the antiserum reacted quantitatively with small amounts of radioactively labelled purified tropoelastin prepared from embryonic-chick aortae. The antiserum did not cross-react with chick procollagen, and the antiserum
P, Christner, M, Dixon, A, Cywinski, J, Rosenbloom   +3 more
openaire   +2 more sources

Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16

Archives of Medical Science, 2020
Introduction Androgenetic alopecia (AGA) or male pattern baldness is a polygenic disease with a high prevalence in the Caucasian population, with psychosocial implications. However, the molecular mechanisms involved are unknown. The aim of this study was
Miguel A. Ortega, María J. Álvarez-Rocha, Ángel Asúnsolo, Beatriz Romero, Santiago Coca, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla   +7 more
doaj   +1 more source