Results 31 to 40 of about 4,779 (198)

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Frontiers in Genetics, 2021
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin.
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss, Clair Baldock   +7 more
doaj   +1 more source

Allysine modifications perturb tropoelastin structure and mobility on a local and global scale

Matrix Biology Plus, 2019
Elastin provides elastic tissues with resilience through stretch and recoil cycles, and is primarily made of its extensively cross-linked monomer, tropoelastin.
Jazmin Ozsvar, Anna Tarakanova, Richard Wang, Markus J. Buehler, Anthony S. Weiss   +4 more
doaj   +1 more source

SNPs Mutation of Tropoelastin Gene Affects Tropoelastin mRNA and Elastin Expressions in Human Aortic Smooth Muscle Cells

, 2023
Objectives: We aimed to explore the effects of single nucleotide polymorphisms (SNPs) in tropoelastin gene on tropoelastin mRNA and elastin expressions in human aortic smooth muscle cells (HASMCs). Methods: Two SNP loci, rs2071307(G/A) and rs1785598(G/C),
Jie, Yue
core   +1 more source

Coarse-grained model of tropoelastin self-assembly into nascent fibrils

Materials Today Bio, 2019
Elastin is the dominant building block of elastic fibers that impart structural integrity and elasticity to a range of important tissues, including the lungs, blood vessels, and skin.
A. Tarakanova, J. Ozsvar, A.S. Weiss, M.J. Buehler   +3 more
doaj   +1 more source

Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase‐like 1 knockout mouse model

Physiological Reports, 2020
Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson, Ganesh Swaminathan, Shataakshi Dahal, Bruna Couri, Mei Kuang, Anna Rietsch, Robert S. Butler, Anand Ramamurthi, Margot S. Damaser   +8 more
doaj   +1 more source

Perinatal expression of genes that may participate in lipid metabolism by lipid-laden lung fibroblasts

Journal of Lipid Research, 1998
Although a morphologically distinct population of lipid-laden interstitial cells (lipofibroblasts, LF), has been identified, the origins and functions of this population during lung development and disease remain undefined.
Heshun Chen, Sheila Jackson, Melissa Doro, Stephen McGowan   +3 more
doaj   +1 more source

Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity

APL Bioengineering, 2018
Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone nodule formation, would help to improve contact between ...
Edgar A. Wakelin, Giselle C. Yeo, David R. McKenzie, Marcela M. M. Bilek, Anthony S. Weiss   +4 more
doaj   +1 more source

Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1

Biomolecules, 2020
Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A. Boyle, Marie-Paule Jacob, Gilles Faury   +7 more
doaj   +1 more source

Tropoelastin Implants That Accelerate Wound Repair [PDF]

Advanced Healthcare Materials, 2018
AbstractA novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair.
Suzanne M. Mithieux, Behnaz Aghaei‐Ghareh‐Bolagh, Leping Yan, Kekini V. Kuppan, Yiwei Wang, Francia Garces‐Suarez, Zhe Li, Peter K. Maitz, Elizabeth A. Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi‐Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K. Kumashiro, Glenn Edwards, Anthony S. Weiss   +17 more
openaire   +2 more sources

Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation [PDF]

, 2019
International audienceAims: Dysfunctional matrix turnover is present at sites of abdominal aortic aneurysm (AAA) and leads to the accumulationof monomeric tropoelastin rather than cross-linked elastin.
Bakewell, Robert, Lacerda, Sara, Botnar, René M., Martins Vasco De Lacerda, Sara, Phinikaridou, A., Andia, Marcelo, Botnar, René, Lorrio Gonzalez, Silvia, Botnar, Rene Michael; id_orcid, Lorrio, Silvia, Smith, Alberto, Rashid, Imran, Bakewell, R., Phinikaridou, Alkystis; id_orcid, Lavín, B., Lavin, Begoña, Andia Kohnenkampf, Marcelo Edgardo, Lavin Plaza, Begona, Smith, A., Lacerda, S., Lorrio, S., Botnar, René Michael, Phinikaridou, Alkystis, Rashid, I.   +23 more
core   +1 more source