Results 11 to 20 of about 4,779 (198)

Tropoelastin [PDF]

Circulation: Cardiovascular Imaging, 2018
Background: Elastolysis and ineffective elastogenesis favor the accumulation of tropoelastin, rather than cross-linked elastin, in atherosclerotic plaques. We developed gadolinium-labeled tropoelastin-specific magnetic resonance contrast agents for tropoelastin imaging in animal models. Methods
Phinikaridou, Alkystis, Lacerda, Sara, Lavin, Begoña, Andia, Marcelo E., Smith, Alberto, Saha, Prakash, Botnar, René M.   +6 more
core   +9 more sources

Incorporation of Human Recombinant Tropoelastin into Silk Fibroin Membranes with the View to Repairing Bruch’s Membrane

Journal of Functional Biomaterials, 2015
Bombyx mori silk fibroin membranes provide a potential delivery vehicle for both cells and extracellular matrix (ECM) components into diseased or injured tissues. We have previously demonstrated the feasibility of growing retinal pigment epithelial cells
Audra M. A. Shadforth, Shuko Suzuki, Raphaelle Alzonne, Grant A. Edwards, Neil A. Richardson, Traian V. Chirila, Damien G. Harkin   +6 more
doaj   +2 more sources

Tropoelastin Improves Post-Infarct Cardiac Function [PDF]

Circulation Research, 2023
Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may have more favorable properties within the cardiac scar.
Robert D. Hume, Shaan Kanagalingam, Tejas Deshmukh, Siqi Chen, Suzanne M. Mithieux, Fairooj N. Rashid, Iman Roohani, Juntang Lu, Tram Doan, Dinny Graham, Zoe E. Clayton, Eugene Slaughter, Eddy Kizana, April S. Stempien-Otero, Paula Brown, Liza Thomas, Anthony S. Weiss, James J.H. Chong   +17 more
openaire   +5 more sources

Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse

Indonesian Journal of Obstetrics and Gynecology, 2016
Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and ...
Alvilusia Alvilusia, Amir Fauzi, Azhari Azhari, Wresnindyatsih Wresnindyatsih, Irsan Saleh   +4 more
doaj   +3 more sources

Tropoelastin Expression by Periodontal Fibroblasts

Journal of Dental Research, 2002
Elastic system fibers are load-bearing proteins found in periodontal tissue. There are three types—oxytalan, elaunin, and elastic fibers—which differ in their relative microfibril and elastin contents. Oxytalan fibers are known to be distributed in the periodontal ligaments and gingiva, whereas elaunin and elastic fibers are present only in the gingiva.
E, Tsuruga, K, Irie, Y, Sakakura, T, Yajima   +3 more
openaire   +3 more sources

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Molecular Therapy: Nucleic Acids, 2023
Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization ...
Sonia Golombek, Thomas Hoffmann, Ludmilla Hann, Markus Mandler, Sabine Schmidhuber, Josefin Weber, Young-Tae Chang, Roman Mehling, Andrea Ladinig, Christian Knecht, Johanna Leyens, Christian Schlensak, Hans Peter Wendel, Achim Schneeberger, Meltem Avci-Adali   +14 more
doaj   +5 more sources

Targeted Modulation of Tropoelastin Structure and Assembly [PDF]

ACS Biomaterials Science & Engineering, 2016
Tropoelastin, as the monomer unit of elastin, assembles into elastic fibers that impart strength and resilience to elastic tissues. Tropoelastin is also widely used to manufacture versatile materials with specific mechanical and biological properties.
Yeo, Giselle C., Baldock, Clair, Wise, Steven G., Weiss, Anthony S   +3 more
openaire   +4 more sources

Cultured Human Keratinocytes Express Tropoelastin

Journal of Investigative Dermatology, 1997
We detected elastin mRNA in cultured normal human keratinocytes by RNase protection assay. The content of elastin mRNA was estimated at approximately one-twentieth of that of cultured skin fibroblasts. Tropoelastin polypeptide with a molecular weight of 68 kDa was detected in the preparation of culture medium of normal human keratinocytes by western ...
Kajiya, Hiroyoshi, Tanaka, Nobuhiko, Inazumi, Toyoko, Seyama, Yoshiyuki, Tajima, Shingo, Ishibashi, Akira   +5 more
openaire   +3 more sources

MMP-14 degrades tropoelastin and elastin

Biochimie, 2019
Matrix metalloproteinases are a class of enzymes, which degrade extracellular matrix components such as collagens, elastin, laminin or fibronectin. So far, four matrix metalloproteinases have been shown to degrade elastin and its precursor tropoelastin, namely matrix metalloproteinase-2, -7, -9 and -12.
Natalia Miekus, Chiara Luise, Wolfgang Sippl, Tomasz Baczek, Christian E.H. Schmelzer, Andrea Heinz   +5 more
core   +5 more sources

Heparan sulphate interacts with tropoelastin, with some tropoelastin peptides and is present in human dermis elastic fibers

Matrix Biology, 2005
A number of reports point to the presence of proteoglycans and/or glycosaminoglycans within elastic fibers in normal and in pathological conditions. We present data that heparan sulphate (HS)-containing proteoglycans are associated with normal elastic fibers in human dermis and that isolated HS chains interact in vitro with recombinant tropoelastin and
GHEDUZZI, Dealba, GUERRA, Deanna, B. Bochicchio, A. Pepe, AM Tamburro, QUAGLINO, Daniela, S. Mithieux, RONCHETTI, Ivonne, AS Weiss   +8 more
core   +5 more sources