Preoperative Skin Conditioning: Extracellular Matrix Clearance and Skin Bed Preparation, A New Paradigm. [PDF]
This paper introduces the concept of "skin bed preparation" prior to surgical procedures. Following the theory of chronic wound bed preparation and adapting the skin model to one of chronic wound changes related to extrinsic and intrinsic factors, a ...
Cohen, Steven R+2 more
core
Adipocytes, aldosterone and obesity-related hypertension [PDF]
Understanding the mechanisms linking obesity with hypertension is important in the current obesity epidemic as it may improve therapeutic interventions.
Friederich-Persson, Malou+3 more
core +1 more source
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao+18 more
wiley +1 more source
THE present report describes the conversion of insoluble aorta elastin to a gel. Wood1 recently described the preparation of an elastin gel from a soluble protein derived from cattle ligamentum nuchae. These observations may have some bearing on the relationship between collagen and elastin2–5.
Kenneth C. Robbins, Norman H Grant
openaire +2 more sources
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam+4 more
core +1 more source
Electrochemical‐Genetic Programming of Protein‐Based Magnetic Soft Robots for Active Drug Delivery
This manuscript presents a protein‐based soft robot for active drug delivery. Stimuli‐responsive protein is rationally designed and processed into the substrate of robots. Superparamagnetic Fe3O4 nanoparticles are patterned on the substrate using an electrochemical method, enabling the robot to respond to external physical fields.
Hang Zhao+12 more
wiley +1 more source
Regional biomechanical and histological characterisation of the passive porcine urinary bladder: Implications for augmentation and tissue engineering strategies [PDF]
The aim of this study was to identify and quantify potential regional and directional variations in the quasistatic uniaxial mechanical properties of the passive urinary bladder wall.
Bolland, Fiona+4 more
core +1 more source
The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen+6 more
wiley +1 more source
A model for the anisotropic response of fibrous soft tissues using six discrete fibre bundles [PDF]
The development of accurate constitutive models of fibrous soft-tissues is a challenging problem. Many consider the tissue to be a collection of fibres with a continuous distribution function representing their orientations. A novel discrete fibre model
Flynn, C., Nielsen, P., Rubin, M. B.
core +1 more source
Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications
This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster+2 more
wiley +1 more source