Results 91 to 100 of about 795 (185)

Risperidone induces osteoporosis and neuropsychiatric treatment resistance via SMPD1-lysosome-mediated ferroptosis: dual rescue by active vitamin D analog ED-71

Journal of Advanced Research
Introduction: Risperidone (RIS), a second-generation antipsychotic for schizophrenia (SZ), is linked to osteoporosis and suboptimal symptom resolution. The shared cellular mechanisms underlying these cross-tissue toxicities (bone and hippocampus) remain ...
Yajun Cui, Ke Ma, Lingshuang Li, Xuejie Lin, Yu Ji, Haipeng Si, Hongrui Liu, Minqi Li   +7 more
doaj   +1 more source

Eldecalcitol is more effective for promoting osteogenesis than alfacalcidol in Cyp27b1-knockout Mice

, 2018
Calcium (Ca) absorption from the intestinal tract is promoted by active vitamin D (1α,25D3). Vitamin D not only promotes Ca homeostasis, but it also inhibits bone resorption and promotes osteogenesis, thus playing a role in the maintenance of normal bone
Keigo Isomoto, Yoshitomo Suhara, Yoshihisa Hirota, Toshiyuki Sakaki, Kimie Nakagawa, Noboru Kubodera, Maya Kamao, Toshio Okano, Naomi Osakabe   +8 more
core   +1 more source

FGF23, Hypophosphatemia, and Emerging Treatments

JBMR Plus, 2019
FGF23 is an important hormonal regulator of phosphate homeostasis. Together with its co‐receptor Klotho, it modulates phosphate reabsorption and both 1α‐hydroxylation and 24‐hydroxylation in the renal proximal tubules.
Erik A Imel, Andrew Biggin, Aaron Schindeler, Craig F Munns   +3 more
doaj   +1 more source

Recent Advancements Towards the Use of Vitamin D Isoforms and the Development of Their Synthetic Analogues as New Therapeutics

Biomedicines
Vitamin D and its metabolites are essential in various physiological processes, including muscle strength, metabolism, antifibrotic activity, and immune regulation.
Rajiv Patel, Nandini, Harsha Kharkwal, Moumita Saha, Murugesan Sankaranarayanan, Saurabh Sharma, Subhash Chander   +6 more
doaj   +1 more source

ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1

Drug Design, Development and Therapy
Ting Liu,1,2 Luxu Wang,1– 3 Tuo Shi,4 Hongrui Liu,1,2 Bo Liu,5 Jie Guo,1,2 Minqi Li1,2,5 1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Liu T, Wang L, Shi T, Liu H, Liu B, Guo J, Li M   +6 more
doaj  

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

Drug Design, Development and Therapy, 2020
Cancan Huang, Chaotao Zhang, Panpan Yang, Rui Chao, Ziqi Yue, Congshan Li, Jie Guo, Minqi Li Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M   +7 more
doaj  

DataSheet_1_Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis.docx

BackgroundElderly people are at high risk of falls due to decreased muscle strength. So far, there is currently no officially approved medication for treating muscle strength loss.
Yali Ling (14171981), Miaoying Lin (17881868), Lei Qiu (478778), Ya Ding (1863115), An Xiong (17881865), Xuedi Xia (17881871), Rui Wang (52434), Haibo Li (629817), Ruoman Sun (17881877), Dexing Dai (17881874), Feng Xu (89016), Zhongjian Xie (4633099)   +11 more
core   +1 more source

The Computational Interaction Analyses of Some Vitamin D-Related Compounds with Sterol 14-Demethylase (CYP51) – Could It Be a Glimmer of Hope to Find New Anti-Mucormycotic Drugs Extracted from Plants-Derived Sterols?

Natural Product Communications
Introduction Many vitamin D analogs and sterols-related compounds have been identified and extracted from several plants including Solanaceae species .
Mohammed Helmy Faris Shalayel, Ghassab M. Al-Mazaideh, Majed Meshal Almutairi, Wael A. Alsubhi, Abdullah K. Althaiban   +4 more
doaj   +1 more source

Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease

JCI Insight
Despite their beneficial actions as immunosuppressants, glucocorticoids (GC) have devastating effects on the musculoskeletal and cardiac systems, as long-term treated patients exhibit high incidence of falls, bone fractures, and cardiovascular events ...
Amy Y. Sato, Meloney Cregor, Kevin McAndrews, Charles A. Schurman, Eric Schaible, Jennifer Shutter, Punit Vyas, Bhawana Adhikari, Monte S. Willis, Marjan Boerma, Tamara Alliston, Teresita Bellido   +11 more
doaj   +1 more source

Eldecalcitol and calcium supplementation in Chinese women with postmenopausal osteoporosis: a prospective observational cohort study. [PDF]

J Bone Miner Metab
Jiang Y, Zeng Y, Xin L, Chen W, Xu Y, Tian S, Wang Q, Li J, Chen S, Lin X, Ying Q, Chiba S, Yamagiwa C, Yamaguchi T, Ke Z, Xia W, Takeuchi Y.   +16 more
europepmc   +1 more source