Results 91 to 100 of about 756 (179)

The proportion of adverse drug reactions reported to the manufacturer within 2 weeks of onset.

, 2015
(A) capecitabine, (B) eldecalcitol, (C) epoetin beta pegol, (D) peginterferon alfa-2a, and (E) sevelamer hydrochloride. Error bars represent the 95% confidence intervals.
Seigo Okugawa (733308), Kotonari Aoki (733302), Terumi Nakayama (733307), Takumi Kobayashi (733305), Takuya Kawamata (733303), Minami Tomita (733310), Yoshihiko Sugimura (733309), Yoichiro Takahashi (733311), Hiroshi Kuriki (733306), Shinichi Matsuda (733301), Tetsuji Kimotsuki (733304)   +10 more
core   +1 more source

FGF23, Hypophosphatemia, and Emerging Treatments

JBMR Plus, 2019
FGF23 is an important hormonal regulator of phosphate homeostasis. Together with its co‐receptor Klotho, it modulates phosphate reabsorption and both 1α‐hydroxylation and 24‐hydroxylation in the renal proximal tubules.
Erik A Imel, Andrew Biggin, Aaron Schindeler, Craig F Munns   +3 more
doaj   +1 more source

Recent Advancements Towards the Use of Vitamin D Isoforms and the Development of Their Synthetic Analogues as New Therapeutics

Biomedicines
Vitamin D and its metabolites are essential in various physiological processes, including muscle strength, metabolism, antifibrotic activity, and immune regulation.
Rajiv Patel, Nandini, Harsha Kharkwal, Moumita Saha, Murugesan Sankaranarayanan, Saurabh Sharma, Subhash Chander   +6 more
doaj   +1 more source

ED-71 Ameliorates Bone Loss in Type 2 Diabetes Mellitus by Enhancing Osteogenesis Through Upregulation of the Circadian Rhythm Coregulator BMAL1

Drug Design, Development and Therapy
Ting Liu,1,2 Luxu Wang,1– 3 Tuo Shi,4 Hongrui Liu,1,2 Bo Liu,5 Jie Guo,1,2 Minqi Li1,2,5 1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Liu T, Wang L, Shi T, Liu H, Liu B, Guo J, Li M   +6 more
doaj  

Eldecalcitol Inhibits LPS-Induced NLRP3 Inflammasome-Dependent Pyroptosis in Human Gingival Fibroblasts by Activating the Nrf2/HO-1 Signaling Pathway

Drug Design, Development and Therapy, 2020
Cancan Huang, Chaotao Zhang, Panpan Yang, Rui Chao, Ziqi Yue, Congshan Li, Jie Guo, Minqi Li Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Huang C, Zhang C, Yang P, Chao R, Yue Z, Li C, Guo J, Li M   +7 more
doaj  

Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats

Glucocorticoid causes secondary osteoporosis and myopathy, characterized by type II muscle fiber atrophy. We examined whether a new vitamin D3 analog, eldecalcitol, could inhibit glucocorticoid-induced osteopenia or myopathy in rats and determined ...
Shiraishi, Ayako, Fujii, Masashi, Sakai, Sadaoki, Segawa, Toyohito, Ohuchi, Kentaro, Shimada, Yoichi, Miyakoshi, Naohisa, Kinoshita, Hayato, Kasukawa, Yuji, Sato, Chie   +9 more
core  

The Computational Interaction Analyses of Some Vitamin D-Related Compounds with Sterol 14-Demethylase (CYP51) – Could It Be a Glimmer of Hope to Find New Anti-Mucormycotic Drugs Extracted from Plants-Derived Sterols?

Natural Product Communications
Introduction Many vitamin D analogs and sterols-related compounds have been identified and extracted from several plants including Solanaceae species .
Mohammed Helmy Faris Shalayel, Ghassab M. Al-Mazaideh, Majed Meshal Almutairi, Wael A. Alsubhi, Abdullah K. Althaiban   +4 more
doaj   +1 more source

Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease

JCI Insight
Despite their beneficial actions as immunosuppressants, glucocorticoids (GC) have devastating effects on the musculoskeletal and cardiac systems, as long-term treated patients exhibit high incidence of falls, bone fractures, and cardiovascular events ...
Amy Y. Sato, Meloney Cregor, Kevin McAndrews, Charles A. Schurman, Eric Schaible, Jennifer Shutter, Punit Vyas, Bhawana Adhikari, Monte S. Willis, Marjan Boerma, Tamara Alliston, Teresita Bellido   +11 more
doaj   +1 more source

Prior treatment, not vitamin D, predicts romosozumab response in 314 osteoporosis patients: A retrospective cohort study. [PDF]

Bone Rep
Nakano R, Ichisawa A, Saruta K, Kogawa M, Fukuda A.   +4 more
europepmc   +1 more source

Mechanistic actions of eldecalcitol and alfacalcidol across the muscle-metabolic axis: A selectivity perspective in sarcopenia and type 2 diabetes. [PDF]

iScience
Cambria MT, Campanella M, Russo C, Agafonova A, Surdo S, Valle MS, Malaguarnera L.   +6 more
europepmc   +1 more source