Results 141 to 150 of about 756 (179)

Relationship between the effect of eldecalcitol and serum 25(OH)D level [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2014
In previous studies, we demonstrated that 12-month treatment with 0.75μg/day eldecalcitol increased bone mineral density in osteoporotic patients regardless of serum 25-hydroxyvitamin D (25(OH)D) level, and in a 3-year randomized double-blind clinical trial, eldecalcitol significantly reduced the incidences of vertebral and wrist fractures compared to ...
Hitoshi Saito, Toshio Matsumoto
exaly   +4 more sources

Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2014
Calcitriol (1α,25-dihydroxyvitamin D3, 1α,25(OH)2D3) is an essential hormone that works in cooperation with parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) to regulate calcium and phosphorus homeostasis.
Hitoshi Saito
exaly   +2 more sources

Large-Scale Synthesis of Eldecalcitol

Organic Process Research and Development, 2021
Shin H
exaly   +2 more sources

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Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism

Journal of Steroid Biochemistry and Molecular Biology, 2010
Eldecalcitol [ED-71, 2beta-(3-hydroxypropyloxy)-1,25-dihydroxyvitamin D3] increases lumbar and hip bone mineral density (BMD) in a dose-dependent manner in osteoporotic patients with vitamin D supplementation. However, there has been no head-to-head comparison of the effects of eldecalcitol with alfacalcidol on bone and calcium metabolism in human ...
Toshio Matsumoto
exaly   +3 more sources

Spotlight on Eldecalcitol in Osteoporosis†

Drugs & Aging, 2012
Eldecalcitol (1α,25[OH](2)-2β-(3-hydroxypropyloxy)vitamin D(3); ED-71; Edirol®) is an orally administered analogue of active vitamin D (calcitriol) that is available in Japan for the treatment of osteoporosis at a dosage of 0.75 μg/day. In a randomized, double-blind, placebo-controlled, dose-ranging trial, eldecalcitol reduced markers of bone turnover ...
Mark, Sanford, Paul L, McCormack
openaire   +2 more sources

Eldecalcitol is more effective for the prevention of osteoporotic fractures than alfacalcidol [PDF]

Journal of Bone and Mineral Metabolism, 2013
Eldecalcitol, a vitamin D3 analogue, significantly reduces the risk of new vertebral fractures and increases bone mineral density (BMD) more than does alfacalcidol. To determine the effect of eldecalcitol on the incidence of all fragility fractures caused by osteoporosis, we conducted post hoc analyses of the phase III clinical trial to evaluate the ...
Masataka Shiraki, Toshio Matsumoto, Masao Fukunaga   +2 more
exaly   +3 more sources

Large-Scale Synthesis of Eldecalcitol

Organic Process Research & Development, 2020
Industrial-scale synthesis of eldecalcitol is described. AA highly diastereoselective epoxidation of p-methoxybenzyl (PMB) protected dienol at room temperature provides the key epoxide intermediate...
Hyung Wook Moon, Seung Jong Lee, Seong Hu Park, Se Gyo Jung, In A Jung, Chang Hun Seol, Seung Woo Kim, Seon Mi Lee, Bogonda Gangganna, Seokhwi Park, Kee-Young Lee, Chang-Young Oh, Juyoung Song, Jaehun Jung, Ji Soo Heo, Kang Hee Lee, Hae Sol Kim, Won Taek Lee, Areum Baek, Hyunik Shin   +19 more
openaire   +1 more source

Eldecalcitol is less effective in suppressing parathyroid hormone compared to calcitriol in vivo

Journal of Steroid Biochemistry and Molecular Biology, 2010
Eldecalcitol is a vitamin D3 analog under clinical development for the treatment of osteoporosis. Previous studies have shown that the binding activities of eldecalcitol to the serum vitamin D binding protein (DBP) and the vitamin D receptor (VDR) are 421.9% and 44.6% of those of calcitriol, respectively, and also, suppressed parathyroid hormone (PTH ...
Hitoshi Saito
exaly   +3 more sources

Effects of eldecalcitol alone or a bone resorption inhibitor with eldecalcitol on bone mineral density, muscle mass, and exercise capacity for postmenopausal women with distal radius fractures

Journal of Orthopaedic Science, 2022
Distal radius fractures are often the first fractures experienced by adults with osteoporosis, and such fractures provide an opportunity for treatment to prevent a domino effect of future fractures. Most of these fractures result from falls, which may be related to the individual's limb muscle mass, strength, and exercise capacity.
Kazushige, Maeda, Junya, Imatani, Shiro, Moritani, Hidenori, Kondo   +3 more
openaire   +2 more sources

Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx‐1

Oral Diseases, 2021
Abstract Objectives This study aimed to investigate the role of eldecalcitol in the progression of oral squamous cell carcinoma and to explore the related mechanism. Materials and Methods The effects of eldecalcitol ...
Yupu Lu, Yuying Kou, Yuan Gao, Panpan Yang, Shanshan Liu, Fan Zhang, Minqi Li   +6 more
openaire   +2 more sources