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Minodronate for severe multiple vertebral fractures due to pregnancy- and lactation-associated osteoporosis: a case report and literature review. [PDF]

Ther Adv Musculoskelet Dis
Ota K, Asanuma Y, Hirasawa H, Ohta H, Takahashi T.   +4 more
europepmc   +1 more source

Romosozumab for managing severe osteoporosis in patients undergoing kidney transplantation: a retrospective case series. [PDF]

JBMR Plus
Tominaga A, Wada K, Kato Y, Okazaki K.
europepmc   +1 more source

Pulmonary bone marrow embolism caused by robot-assisted lobectomy: a case report. [PDF]

J Surg Case Rep
Hato T, Kashimada H, Yamaguchi M, Inoue Y, Fukuda H, Gika M, Kamiyama D, Higashi M, Kohno M.   +8 more
europepmc   +1 more source

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Comparison of the Effects of Eldecalcitol and Alfacalcidol on Bone and Calcium Metabolism

Journal of Steroid Biochemistry and Molecular Biology, 2010
Eldecalcitol [ED-71, 2beta-(3-hydroxypropyloxy)-1,25-dihydroxyvitamin D3] increases lumbar and hip bone mineral density (BMD) in a dose-dependent manner in osteoporotic patients with vitamin D supplementation. However, there has been no head-to-head comparison of the effects of eldecalcitol with alfacalcidol on bone and calcium metabolism in human ...
Toshio Matsumoto, Fumiaki Takahashi
exaly   +3 more sources

Spotlight on Eldecalcitol in Osteoporosis†

Drugs & Aging, 2012
Eldecalcitol (1α,25[OH](2)-2β-(3-hydroxypropyloxy)vitamin D(3); ED-71; Edirol®) is an orally administered analogue of active vitamin D (calcitriol) that is available in Japan for the treatment of osteoporosis at a dosage of 0.75 μg/day. In a randomized, double-blind, placebo-controlled, dose-ranging trial, eldecalcitol reduced markers of bone turnover ...
Mark, Sanford, Paul L, McCormack
openaire   +2 more sources

Eldecalcitol Is More Effective for the Prevention of Osteoporotic Fractures Than Alfacalcidol [PDF]

Journal of Bone and Mineral Metabolism, 2013
Eldecalcitol, a vitamin D3 analogue, significantly reduces the risk of new vertebral fractures and increases bone mineral density (BMD) more than does alfacalcidol. To determine the effect of eldecalcitol on the incidence of all fragility fractures caused by osteoporosis, we conducted post hoc analyses of the phase III clinical trial to evaluate the ...
Masataka Shiraki, Toshio Matsumoto, Masao Fukunaga   +2 more
exaly   +3 more sources

Eldecalcitol

Drugs, 2011
Eldecalcitol (1α,25[OH](2)-2β-(3-hydroxypropyloxy)vitamin D(3); ED-71; Edirol®) is an orally administered analogue of active vitamin D (calcitriol) that is available in Japan for the treatment of osteoporosis. Two randomized, double-blind, multicentre trials were conducted in patients with osteoporosis.
Mark, Sanford, Paul L, McCormack
openaire   +2 more sources

Large-Scale Synthesis of Eldecalcitol

Organic Process Research & Development, 2020
Industrial-scale synthesis of eldecalcitol is described. AA highly diastereoselective epoxidation of p-methoxybenzyl (PMB) protected dienol at room temperature provides the key epoxide intermediate...
Hyung Wook Moon, Seung Jong Lee, Seong Hu Park, Se Gyo Jung, In A Jung, Chang Hun Seol, Seung Woo Kim, Seon Mi Lee, Bogonda Gangganna, Seokhwi Park, Kee-Young Lee, Chang-Young Oh, Juyoung Song, Jaehun Jung, Ji Soo Heo, Kang Hee Lee, Hae Sol Kim, Won Taek Lee, Areum Baek, Hyunik Shin   +19 more
openaire   +1 more source

Relationship Between the Effect of Eldecalcitol and Serum 25(OH)D Level

Journal of Steroid Biochemistry and Molecular Biology, 2014
In previous studies, we demonstrated that 12-month treatment with 0.75μg/day eldecalcitol increased bone mineral density in osteoporotic patients regardless of serum 25-hydroxyvitamin D (25(OH)D) level, and in a 3-year randomized double-blind clinical trial, eldecalcitol significantly reduced the incidences of vertebral and wrist fractures compared to ...
Hitoshi Saito, Toshio Matsumoto
exaly   +3 more sources

Effects of eldecalcitol alone or a bone resorption inhibitor with eldecalcitol on bone mineral density, muscle mass, and exercise capacity for postmenopausal women with distal radius fractures

Journal of Orthopaedic Science, 2022
Distal radius fractures are often the first fractures experienced by adults with osteoporosis, and such fractures provide an opportunity for treatment to prevent a domino effect of future fractures. Most of these fractures result from falls, which may be related to the individual's limb muscle mass, strength, and exercise capacity.
Kazushige, Maeda, Junya, Imatani, Shiro, Moritani, Hidenori, Kondo   +3 more
openaire   +2 more sources