Results 131 to 140 of about 3,263,574 (391)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Respiratory syncytial virus infection in elderly and high-risk adults.

open access: yesNew England Journal of Medicine, 2005
BACKGROUND Respiratory syncytial virus (RSV) is an increasingly recognized cause of illness in adults. Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine ...
A. Falsey   +4 more
semanticscholar   +1 more source

Anaemia in the elderly. [PDF]

open access: yesBMJ, 1973
Anaemia is always pathological and the clinical impression of its presence or absence often erroneous; it is not a con comitant of ageing. The reported incidence has varied greatly. Pincherle and Shanks1 found it in only 0*42% of 2,000 busi ness executives, 300 of whom were over 60 years.
openaire   +3 more sources

Benefit of Brown Rice Feeding on Elderly Insomnia [PDF]

open access: yes, 2015
Difficulty falling asleep or insomnia is one of health problems in elderly. Age is one of the risk factor of insomnia. Tryptophan in brown rice can stimulate the formation of serotonin.
Hidayati, T. (Titiek)   +4 more
core  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Internet-of-Things and Smart Homes for Elderly Healthcare: An End User Perspective

open access: yesIEEE Access, 2018
Although an Internet-of-Things-based smart home solution can provide an improved and better approach to healthcare management, yet its end user adoption is very low.
Debajyoti Pal   +3 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure.

open access: yesNew England Journal of Medicine, 1995
BACKGROUND Congestive heart failure is the most common indication for admission to the hospital among older adults. Behavioral factors, such as poor compliance with treatment, frequently contribute to exacerbations of heart failure, a fact suggesting ...
M. Rich   +5 more
semanticscholar   +1 more source

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