Results 171 to 180 of about 5,662 (220)
Some of the next articles are maybe not open access.
Mechanisms of electrochemotherapy
Advanced Drug Delivery Reviews, 1999Electrochemotherapy is a new therapeutic approach providing delivery into cell interiors of nonpermeant drugs with intracellular targets. It is based on the local application of short and intense electric pulses that transiently permeabilize cells in tissues. To date, its main application has been the treatment of tumor nodules when the electric pulses
, Mir, , Orlowski
openaire +2 more sources
Electrochemotherapy for digital chondrosarcoma
Journal of Orthopaedic Science, 2003Electrochemotherapy (ECT) delivers nonpermeable anticancer drugs to cell interiors by temporally increasing the permeability of the cytoplasmic membrane under locally applied pulsating electrical stimuli. This treatment results in consistent and enhanced pharmacological effects of drugs on the targeted tissue.
Tominaga Shimizu +8 more
openaire +2 more sources
Clinical applications of electrochemotherapy
Advanced Drug Delivery Reviews, 1999Electrochemotherapy is a novel treatment which consists of a combination of a chemotherapeutic agent and pulsed electric fields. This relatively new treatment modality relies on the physical effects of locally applied electric fields to temporarily destabilize cell membranes in the presence of a drug to allow increased uptake of the agent into the ...
, Heller, , Gilbert, , Jaroszeski
openaire +2 more sources
The Basis of Electrochemotherapy
2003Antitumor electrochemotherapy is a treatment of solid tumors which combines a cytotoxic nonpermeant drug, like bleomycin, with locally delivered permeabilizing electric pulses (1-3). More generally, a new form of vectorization is achieved by the combination of nonpermeant molecules with intracellular targets and of a physical perturbation that locally ...
L M, Mir, S, Orlowski
openaire +2 more sources
Novel electrode designs for electrochemotherapy
Biochimica et Biophysica Acta (BBA) - General Subjects, 1997Direct current pulses for electrochemotherapy treatment are typically administered using two parallel plate electrodes that are placed on either side of the tumor. This simple design has produced high response rates (70 to 85%) in animal studies and in clinical trials. However, parallel plate electrodes are not suitable for all situations.
R A, Gilbert, M J, Jaroszeski, R, Heller
openaire +2 more sources
Electrochemotherapy of melanoma cutaneous metastases
Orvosi Hetilap, 2010Az elektrokemoterápia daganatok bőráttéteinek palliatív kezelésére alkalmas eljárás, amelynek során nagy energiájú elektromos impulzusok hatására a sejtek membránja áteresztővé válik olyan anyagok, így kemoterapeutikumok számára, amelyek egyébként nem vagy csak kismértékben kerülnének a sejt belsejébe, ezáltal megnövelve azok citotoxikus hatását ...
Erika, Kis +5 more
openaire +2 more sources
[Progress in electrochemotherapy].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2005Electrochemotherapy (ECT) is a novel cancer treatment in which electric pulses (EPs) inducing cell membrane pored (electroporation) are used as a means of delivering antitumor drugs to the cytoplasm of cancer cells. The minimal thresholds of electric field strength of in vitro tumor cell line and tumor tissue are 450-650 V/cm and 400-600 V/cm ...
Kong, Yang, Bisong, Yue, Zishu, Wang
openaire +1 more source
[Anaesthesia in Electrochemotherapy].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2020Electrochemotherapy (ECT) is a symptom control method for inoperable or exulcerating cutaneous metastases or skin cancer. With the help of electroporation, an enhancement of the efficacy of the administered chemotherapeutic agent, bleomycin or cisplatin, is achieved, which leads to a local reduction of the metastases and thereby has a low impact on the
Christian, Volberg, Martin, Gschnell
openaire +1 more source
Utility of electrochemotherapy in melanoma treatment
Current Opinion in Oncology, 2012In the present study, the role of electrochemotherapy (ECT) in the advanced melanoma setting, either as alternative treatment modality to conventional therapies or as palliative care, is reviewed and the perspective to combine ECT with biological response modifiers and immunotherapeutic compounds is discussed.ECT refers to the combination of ...
Alessandro Testori +2 more
openaire +2 more sources
[Electrochemotherapy in metastatic melanoma].
Orvosi hetilap, 2023In metastatic melanoma, despite the increased survival rates with new innovative therapies, therapeutic response is still quite heterogenous, not always durable. In the case of oligoprogression, several additional therapeutic modalities are available such as electrochemotherapy in the local treatment of cutaneous or subcutaneous metastases.Analysis of ...
Mihály, Kispál +4 more
openaire +1 more source