Results 81 to 90 of about 5,662 (220)

Long term effectiveness of electrochemotherapy for the treatment of lower lip squamous cell carcinoma [PDF]

, 2018
Purpose: Electrochemotherapy (ECT) is a therapeutic approach based on the local application of electrical pulses that permeabilize cell membranes to enhance the uptake of low-permeant chemotherapeutic agents, thus increasing their cytotoxic effects ...
Cortese, A., Gargiulo, M., Murphy, D.C., Parascandolo, S., Razzano, S., Serra Mestre, J.M.   +5 more
core   +1 more source

Scrotal squamous cell carcinoma: Two HPV‐negative cases with probable UV‐ induced pathogenesis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Daniel Craus, Ulrike Wieland, Steffi Silling, Julia Hyun, Milan Vidakovic, Frank Oellig, Alexander Kreuter, Valentina Laura Müller   +7 more
wiley   +1 more source

Tumor Electrophysiology in Precision Tumor Therapy

iMetaMed, Volume 1, Issue 1, September 2025.
This review highlights tumor electrophysiological hallmarks as therapeutic targets in precision oncology. We examine how membrane potential alterations and ion channel fingerprints drive malignancy, and how targeted intervention—including channel‐specific drugs, electric field therapies, and nanodrug delivery systems—can disrupt these processes ...
Kailai Li, Yasi Zhang, Yue Qian, Hu Qin, Hongtian Zhang, Chaoqun Li, Changmin Peng, Jian Zhang, Suyin Feng   +8 more
wiley   +1 more source

GaN-Based Versatile Waveform Generator for Biomedical Applications of Electroporation

IEEE Access, 2020
Biomedical applications often require high-performance power supplies for diagnosis and treatment systems. In particular, modern electroporation techniques for cancer treatment require high-voltage generators with versatile waveform generation.
Hector Sarnago, Jose M. Burdio, Tomas Garcia-Sanchez, Lluis M. Mir, Ignacio Alvarez-Gariburo, Oscar Lucia   +5 more
doaj   +1 more source

Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53 [PDF]

, 2012
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours.
Campo, M., Finlay, M., Morgan, I.M., Nasir, L., Yuan, Z.   +4 more
core   +3 more sources

Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis

Phytotherapy Research, Volume 39, Issue 9, Page 4230-4246, September 2025.
ABSTRACT Propolis is a plant‐derived substance collected by honeybees that has a range of potential therapeutic applications. Propolis consists of resins, waxes, and fatty acids, as well as essential oils and other organic compounds. The pharmacologically active components of propolis include phenols and flavonoids, among others.
Yipeng Lin, Janney Z. Wang, Yihe Niu, Ling Zhu, Rujee K. Duke, Colin C. Duke, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

Acta Dermato-Venereologica, 2019
Skin malignancies of the head and neck inflict significant structural, functional, and cosmetic burdens upon those affected. We retrospectively addressed electrochemotherapy anti-tumour efficacy in head and neck skin cancer patients who were not suitable
Antonio Bonadies, Ettore Bertozzi, Renzo Cristiani, Flavio A. Govoni, Emilia Migliano   +4 more
doaj   +1 more source

Enhancement of electroporation facilitated immunogene therapy via T-reg depletion [PDF]

, 2014
Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumor responses, thus augmenting the potential for immunotherapies ...
A Testori, AMM Eggermont, C Collins, D Alston, D M Soden, F Erdmann, F Tas, G C O' Sullivan, G Tevz, I Martínez-Lacaci, JFM Jacobs, L Finn, L Heller, L J Hall, M de Kruijf, M Sadadcharam, M Tangney, MC Whelan, MC Whelan, ML Lucas, P F Forde, R Dummer, S Bhatia, T R O' Donovan, TJ Curiel, TR Wilson, W L Byrne, W Zou, W Zou   +28 more
core   +1 more source

PD‐L1, PD‐1, and CTLA‐4 mRNA In Situ Expression by Canine Oral Melanoma Cells and Immune Cells of the Tumour Microenvironment

Veterinary and Comparative Oncology, Volume 23, Issue 2, Page 141-151, June 2025.
ABSTRACT Canine oral melanoma (OM) exhibits poor prognosis and limited treatment options. The success of immune checkpoint inhibitors (ICIs) in human melanoma has driven interest in similar therapeutic approaches in the dog, although the immunosuppressive mechanisms adopted by canine OM remain unclear. This study aimed to evaluate the expression of the
Greta Foiani, Erica Melchiotti, Katia Capello, Ilaria Porcellato, Chiara Brachelente, Selina Iussich, Davide Giacobino, Emanuela Morello, Marina Martano, Paolo Buracco, Marta Vascellari   +10 more
wiley   +1 more source

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft [PDF]

, 2011
Background Nucleic acids designed to modulate the expression of target proteins remain a promising therapeutic strategy in several diseases, including cancer. However, clinical success is limited by the lack of efficient intracellular delivery.
Enrico P Spugnini, Annamaria Biroccio, Roberta De Mori, Marco Scarsella, Carmen D'Angelo, Alfonso Baldi, Carlo Leonetti   +6 more
core   +2 more sources