Results 21 to 30 of about 238,119 (262)

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors

open access: yesNature Communications
Genome-wide association studies (GWAS) have identified over 800 loci associated with kidney function, yet the specific genes, variants, and pathways involved remain elusive. By integrating kidney function GWAS with human kidney expression and methylation
Xiujie Liang   +8 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

Evaluation of the Potential of Laser Shock Peening Compared with Cold Expansion for Improving Fatigue Resistance of Riveted Lap Joints of Aerospace Grade 7175 Al Alloy

open access: yesAdvanced Engineering Materials, EarlyView.
This study investigates laser shock peening for enhancing fatigue performance of riveted aerospace aluminum joints. A comparative approach with cold expansion combines fatigue testing and synchrotron X‐ray methods. Integrating mechanical testing with residual stress and strain characterization provides insights into how different treatments affect the ...
Ogün Baris Tapar   +6 more
wiley   +1 more source

Expression and Analysis of Flow-regulated Ion Channels in Xenopus Oocytes

open access: yesBio-Protocol, 2017
Mechanically-gated ion channels play key roles in mechanotransduction, a process that translates physical forces into biological signals. Epithelial and endothelial cells are exposed to laminar shear stress (LSS), a tangential force exerted by flowing ...
Shujie Shi, Marcelo Carattino
doaj   +1 more source

Home Subcutaneous Magnesium Infusion in Refractory Hypomagnesemia: A Case Report

open access: yesKidney Medicine, 2023
We describe a patient with renal magnesium wasting and prolonged, symptomatic hypomagnesemia that was refractory to oral therapies and intermittent intravenous infusion who achieved near-normal serum magnesium levels with subcutaneous magnesium infusions.
Rebecca M. Tokarski   +3 more
doaj   +1 more source

Recent Progress in Oxide‐Based Na‐Ion Conductors

open access: yesAdvanced Engineering Materials, EarlyView.
Recent advances in oxide‐based sodium‐ion conductors are reviewed, focusing on β/β″‐alumina, NASICON‐type compounds, and Na5YSi4O12‐type (N5) silicates, together with emerging perovskite and layered oxides. Improvements in ionic conductivity, compositional tuning, and processing are highlighted.
Bowei Xun   +3 more
wiley   +1 more source

Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin [PDF]

open access: yesInternational Neurourology Journal, 2018
Purpose To determine whether responses to serotonin are altered in bladder strips from cats diagnosed with a naturally occurring form of bladder pain syndrome/interstitial cystitis termed feline interstitial cystitis (FIC). Methods Full thickness bladder
Youko Ikeda   +4 more
doaj   +1 more source

The Impact of High‐Productivity Processing on the Fatigue Failure of an Additive Manufactured Superalloy HAYNES 282

open access: yesAdvanced Engineering Materials, EarlyView.
The low cycle fatigue life of additive manufactured HAYNES® 282® superalloy was investigated for conventional and high‐productivity processing: samples of the former lasted 1400–1700 cycles, while samples of the latter failed at ~ 1200 cycles, at 760 °C and 1% strain.
Abdul Shaafi Shaikh   +3 more
wiley   +1 more source

Targeting neurotrophin and nitric oxide signaling to treat spinal cord injury and associated neurogenic bladder overactivity

open access: yesContinence, 2022
Purpose or the research:: Nearly 300,000 people are affected by spinal cord injury (SCI) with approximately 18,000 new cases annually, according to the National SCI Statistics Center.
Youko Ikeda   +6 more
doaj   +1 more source

Electrolytic Refining of Lead Molten Chloride Electrolytes

open access: yesInternational Journal of Technology, 2017
Three types of antimony and bismuth electrolytic cells to be used for lead electrorefining were developed and tested. The electrolytic cell with the bipolar metallic electrode, the electrolytic cell with two anodes and one cathode, and the electrolytic cell with the porous diaphragm were studied.
Arkhipov, P.   +3 more
openaire   +3 more sources

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