Results 61 to 70 of about 4,690,653 (292)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Український антарктичний журнал, 2020 The article presents the developed artificial neural network for F2 ionosphere layer traces scaling on ionograms obtained using the IPS-42 ionosonde installed at the Ukrainian Antarctic Akademik Vernadsky station.
O. Bogomaz +4 more
doaj +1 more source
Modeling of the cold electron plasma density for radiation belt physics
Frontiers in Astronomy and Space Sciences, 2023 This review focusses strictly on existing plasma density models, including ionospheric source models, empirical density models, physics-based and machine-learning density models.
J.-F. Ripoll +12 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Nanosecond MD of battery cathode materials with electron density description [PDF]
, 2023 Potentials derived with machine learning algorithms achieve the accuracy of high-fidelity quantum mechanical computations such as density functional theory (DFT), while allowing orders of magnitude lower computational time.
Peter Bjørn, Jørgensen +3 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The electron density: experimental determination and theoretical analysis [PDF]
, 1997 Two related lines of research in experimental electron density determination are reported in this thesis. In the first case, the well-proven and popular multipole modeling technique is applied to three high resolution, single-crystal X-ray diffraction ...
Smith, Gary Thomas
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Radio Physics and Radio Astronomy, 2022 Purpose. The object of the study are electron density depletions (‘holes’) occurring in the ionospheric F-region under the action of rocket exhaust products.
L. F. Chernogor
doaj +1 more source