Results 61 to 70 of about 1,261,639 (299)
Review of: "Catecholaminergic Neuron Electron Transport (CNET): A Neural Signaling Mechanism" [PDF]
, 2023 Marinus Toman
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 The formation of persister cells is one mechanism by which bacteria can survive exposure to environmental stresses. We show that Campylobacter jejuni 11168H forms persister cells at a frequency of 10−3 after exposure to 100 × MIC of penicillin G for 24 h.
Helen Morcrette +10 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
ELECTRON BEAM TRANSPORT IN DIELECTRIC TUBES
East European Journal of Physics, 2014 The present paper outlines the results of experimental studying the transport process of pulse high-current beam of electrons about 200 ns in duration with energy under 200 keV through straight and bent glass tubes. A 17 degrees deviation of the electron
O. S. Druj +3 more
doaj
Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I
Frontiers in Chemistry, 2019 Respiratory complex I performs the reduction of quinone (Q) to quinol (QH2) and pumps protons across the membrane. Structural data on complex I have provided spectacular insights into the electron and proton transfer paths, as well as into the long (~30 ...
Outi Haapanen +3 more
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, 2012 Within the framework of nonequilibrium Green's functions, we investigate the thermoelectric transport in a single molecular junction with electron-phonon and electron-electron interactions.
Baowen Li +6 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Surface-Enhanced Raman Scattering in Molecular Junctions
Sensors, 2017 Surface-enhanced Raman scattering (SERS) is a surface-sensitive vibrational spectroscopy that allows Raman spectroscopy on a single molecular scale. Here, we present a review of SERS from molecular junctions, in which a single molecule or molecules are ...
Madoka Iwane +2 more
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Electron turbulence at nanoscale junctions
, 2007 Electron transport through a nanostructure can be characterized in part using concepts from classical fluid dynamics. It is thus natural to ask how far the analogy can be taken, and whether the electron liquid can exhibit nonlinear dynamical effects such
Bushong, Neil +2 more
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