Results 51 to 60 of about 658,351 (342)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Technology Policy, Gender, and Cyberspace [PDF]

open access: yes, 1997
Event based sampling occurs when the time instants are measured everytime the amplitude passes certain pre-defined levels. This is in contrast with classical signal processing where the amplitude is measured at regular time intervals.
Gustafsson, Fredrik, Persson, Niclas
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Affective Medicine: a review of Affective Computing efforts in Medical Informatics [PDF]

open access: yes, 2010
Background: Affective computing (AC) is concerned with emotional interactions performed with and through computers. It is defined as “computing that relates to, arises from, or deliberately influences emotions”. AC enables investigation and understanding
Bamidis, Panagiotis   +2 more
core   +1 more source

MONITORING ANALYSIS OF EFFICIENCY OF PROFESSIONAL COMPUTERS AND SYSTEM REQUIREMENTS FOR THE ORGANIZATION OF ELECTRONIC-EDUCATIONAL ENVIRONMENT OF HIGHER EDUCATION INSTITUTIONS IN THE CONDITIONS OF EDUCATIONAL INCLUSION

open access: yesВестник Мининского университета, 2018
Introduction: in the process of training specialists in various fields of activity, one of the strategic directions is the education of persons with disabilities.
P. A. Egorova   +3 more
doaj   +1 more source

Inovasi Pembelajaran Elektronik dan Tantangan Guru Abad 21 [PDF]

open access: yes, 2018
[Title: Electronic Learning Innovations and 21st Century Teacher Challenges]. The development of information technology that is very rapid in this century has a very significant impact on the world of education, where, the process of transition from the ...
Anggraeni, D. M. (Desak)   +1 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

AG-MS3D-CNN multiscale attention guided 3D convolutional neural network for robust brain tumor segmentation across MRI protocols

open access: yesScientific Reports
Accurate segmentation of brain tumors from multimodal Magnetic Resonance Imaging (MRI) plays a critical role in diagnosis, treatment planning, and disease monitoring in neuro-oncology.
Umesh Kumar Lilhore   +7 more
doaj   +1 more source

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