Results 51 to 60 of about 181,769 (308)

Non-classical computing: feasible versus infeasible [PDF]

open access: yes, 2010
Physics sets certain limits on what is and is not computable. These limits are very far from having been reached by current technologies. Whilst proposals for hypercomputation are almost certainly infeasible, there are a number of non classical ...
Cockshott, P.   +6 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

AG-MS3D-CNN multiscale attention guided 3D convolutional neural network for robust brain tumor segmentation across MRI protocols

open access: yesScientific Reports
Accurate segmentation of brain tumors from multimodal Magnetic Resonance Imaging (MRI) plays a critical role in diagnosis, treatment planning, and disease monitoring in neuro-oncology.
Umesh Kumar Lilhore   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Consecutive Leakage-Resilient and Updatable Lossy Trapdoor Functions and Application in Sensitive Big-Data Environments

open access: yesIEEE Access, 2018
Lossy trapdoor functions (LTFs) are very useful tools in constructing complex cryptographic primitives in a black-box manner, such as injective trapdoor functions, collision-resistant hashes, CCA secure public-key encryption, and so on.
Mingwu Zhang   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

MONITORING ANALYSIS OF EFFICIENCY OF PROFESSIONAL COMPUTERS AND SYSTEM REQUIREMENTS FOR THE ORGANIZATION OF ELECTRONIC-EDUCATIONAL ENVIRONMENT OF HIGHER EDUCATION INSTITUTIONS IN THE CONDITIONS OF EDUCATIONAL INCLUSION

open access: yesВестник Мининского университета, 2018
Introduction: in the process of training specialists in various fields of activity, one of the strategic directions is the education of persons with disabilities.
P. A. Egorova   +3 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Accountants-electronic data processing and management science /operational research specialists relationships: an empirical investigation with special reference to British industry. [PDF]

open access: yes, 1975
This research project was inspired by the researcher's perception of 'the discrepancy between earlier expectations and the present state of the art with regard to the scope, quality, and features of the collaborative efforts of accountants on the one ...
Noor, Anas El-Sayed El-Sayed
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

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