Results 91 to 100 of about 515,492 (292)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Clustering of ions at atomic dimensions in quantum plasmas [PDF]
, 2013 By means of particle simulations of the equations of motion for ions interacting among themselves under the influence of newly discovered Shukla–Eliasson attractive force (SEAF) in a dense quantum plasma, we demonstrate that the SEAF can bring ions ...
Shukla, Padma, Eliasson, Bengt
core +2 more sources
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Coherent forward and backward diffraction radiation of relativistic electrons in a dielectric targets [PDF]
, 2016 During the interaction of the relativistic electrons field with a dielectric target various types of electromagnetic radiation, such as Cerenkov radiation, diffraction radiation, transition radiation can be generated.
Shevelev, Mihail Viktorovich +2 more
core +1 more source
Charge pumping through a single donor atom
New Journal of Physics, 2014 Presented in this paper is a proof-of-concept for a new approach to single electron pumping based on a single atom transistor. By charge pumping electrons through an isolated dopant atom in silicon, precise currents of up to 160 pA at 1 GHz are generated,
G C Tettamanzi, R Wacquez, S Rogge
doaj +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Determination of spin-polarisation for angle-resolved and energy-analysed secondary electrons [PDF]
, 1984 Erbudak M, Müller N. Determination of spin-polarisation for angle-resolved and energy-analysed secondary electrons. Journal of physics, E: Scientific instruments.
Müller, Norbert, Erbudak, M.
core +1 more source