Results 151 to 160 of about 222,058 (260)

Integrated horizontal convective PCR system for clinical diagnostics. [PDF]

Sci Adv
Guo W, Xu M, Tao Y, Liu W, Zhou H, Guan X, Yang R, Ge Z, Xue R, Zhang Z, Zhou H, Ren Y.   +11 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method. [PDF]

PLoS One
Chen W.
europepmc   +1 more source

β‐Lactoglobulin Stabilized Emulsions: A Small Angle X‐Ray Scattering Study on Stability, Ageing, and Thermal Effects

European Journal of Lipid Science and Technology, EarlyView.
This study investigates the structural differences in β‐lactoglobulin stabilized emulsions (BLGem) under various conditions (fresh, aged, and aged at high temperature) using small angle x‐ray scattering (SAXS). The graph shows change in intensity over a range of scattering vectors, with visual evidence of emulsions at different conditions.
Rini P. Ravindranathan, Jon Otto Fossum, Matti Knaapila, Kenneth D. Knudsen   +3 more
wiley   +1 more source

pH-dependent DNA degradation pathways for adeno-associated virus gene therapy. [PDF]

Mol Ther Methods Clin Dev
Plegaria JS, Malecka KA, Lin Q, Vogt A, Ausman K, Lopez De Leon A, Petroff M, Barbacci D.   +7 more
europepmc   +1 more source

Characterization of the Specific Binding Between Aptamers and Cytochrome c With Pressure‐Assisted Capillary Electrophoresis Frontal Analysis

ELECTROPHORESIS, EarlyView.
ABSTRACT Cytochrome c (cyt c) is a heme protein located in the mitochondrial intermembrane space. Because the release of cyt c is a highly specific event in apoptotic signaling, it can serve as an apoptosis‐related marker. To date, three frequently used aptamers for cyt c (Apt40, Apt61, and Apt76) have been selected and applied in the field of sensing.
Shuanghao Wang, Chunliang Li, Shuangshuang Wang, Huihui Li, David Da Yong Chen   +4 more
wiley   +1 more source

Polymerized IgA Monoclonal Gammopathy Simulating Biclonal Gammopathy: A Case Report. [PDF]

Cureus
Mefire K, El Mohtarim O, El Machtani Idrissi S, Bouhsain S, Dami A, Biaz A.   +5 more
europepmc   +1 more source

The Hidden Influence: Impacts of Residual Dimethylformamide in NDSB‐211 on icIEF Separation for Monoclonal Antibodies

ELECTROPHORESIS, EarlyView.
ABSTRACT Monoclonal antibodies (mAbs) present analytical challenges due to their inherent heterogeneity and susceptibility to post‐translational modifications (PTMs) during production and storage. Monitoring of charge heterogeneity profiles by imaged capillary isoelectric focusing (icIEF) has been aided by the use of non‐detergent sulfobetaines (NDSBs),
Delaney Doran, Matthew Myers, Katarina Moravcevic, Steven LaBrenz, Pinger Wang, Xiaoying Ji   +5 more
wiley   +1 more source

Monoclonal immunoglobulins on red blood cells: a potential supplementary diagnostic indicator for monoclonal gammopathies. [PDF]

Front Immunol
Bing B, Yang X, Wang C, Xu L, Cheng S, Liu Y, Wang Q, Zhai C, Zhao B, Wang R, Sun J.   +10 more
europepmc   +1 more source

Capillary‐Based Physicochemical Characterization of Lipid Nanoparticles

ELECTROPHORESIS, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) are widely used for the delivery of nucleic acid (NAs), most notably in gene therapy and messenger ribonucleic acid (mRNA)‐based vaccines. Understanding their physicochemical properties is essential, yet current analytical approaches often fall short in capturing their complexity.
Evrim Ümit Kuzucu, Valentin Schittny, Jörg Huwyler, Maria Anna Schwarz   +3 more
wiley   +1 more source