Results 81 to 90 of about 996,335 (316)

Fluid Dynamics and Electrical Detection of λDNA in Electrode-Embedded Nanochannels

Journal of Biomechanical Science and Engineering, 2013
In the present study, we address theoretical approaches for the experimental results to investigate the flow dynamics of λDNA through a nanochannel in which two nanoelectrodes are integrated.
Satoshi UEHARA, Makusu TSUTSUI, Kentaro DOI, Masateru TANIGUCHI, Satoyuki KAWANO, Tomoji KAWAI   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Single-molecule measurements of trapped and migrating circular DNA during electrophoresis in agarose gels

, 2006
The effect of agarose gel concentration and field strength on the electrophoretic trapping of open (relaxed) circular DNA was investigated using microscopic measurements of individual molecules stained with a fluorescent dye.
Gaigalas, A., Gaigalas, A.,, Cole, K. D., Åkerman, Björn, Åkerman, Björn,, \uc5kerman, Bj\uf6rn, Cole, K. D.,   +6 more
core   +1 more source

Coupling gel electrophoresis with photoluminescence reveals biochrome complexes in modern and fossil shells

Methods in Ecology and Evolution
Polyacrylamide gel electrophoresis is commonly used to visualize mixtures of proteins, such as those embedded in calcareous biominerals. However, it is ineffective for the detection of biochromes, a major class of low molecular weight organic compounds ...
Luca Polacchi, Camille Lutet‐Toti, Olivier Basuyaux, Pierre Gueriau, Marie Albéric, Hélène Pasco, Jérôme Thomas, Didier Merle, Benoît Habermeyer, Roger Guilard, Mathieu Thoury, Frédéric Marin   +11 more
doaj   +1 more source

Genetic diversity of kaffir sorghum accessions from the VIR collection in kafirin-encoding loci

Труды по прикладной ботанике, генетике и селекции
Background. Sorghum is a universal, highly drought-resistant crop, widely cultivated throughout the world. Sorghum grain has a valuable biochemical composition and is utilized in both food and feed production.
N. V. Alpatieva, I. N. Anisimova, M. K. Ryazanova, V. V. Vasipov, R. A. Abdullaev, O. I. Romanova, E. E. Radchenko   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The determination of isoflavones and coumestrol by capillary electrophoresis

Czech Journal of Food Sciences, 2001
The separation of six isoflavones (biochanin A, isoformononetin, formononetin, prunetin, daidzein and genistein) and coumestrol on an uncoated fused-silica capillary electrophoresis column was optimised using alkaline borate buffer as electrolyte and DAD
J. Moravcová, T. Kleinová
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Applications of homochiral metal-organic frameworks in enantioselective adsorption and chromatography separation

, 2014
Chiral separation is of great importance for drug development, pharmacology, and biology. Chiral metal-organic frameworks (MOFs) is a new class of porous solid materials with high surface area, large pore size, high chemical stability, uniformly ...
Liu, Huwei, Li, Xianjiang, Wang, Xin, Bai, Yu, Chang, Cuilan   +4 more
core   +1 more source

Temperature Dependence of Electrophoretic Mobility and Hydrodynamic Radius of Microgels of Poly(N-isopropylacrylamide)

Gels, 2018
Electrostatic interactions in charged microgels, which are dominated by the microgel net charge, play a crucial role in colloidal stabilization and loading of small, charged molecules.
Yasuyuki Maki, Kentaro Sugawara, Daisuke Nagai   +2 more
doaj   +1 more source