Results 101 to 110 of about 68,565 (138)

Research progress of antibody coupling technique in targeted drug delivery

Interdisciplinary Medicine, EarlyView.
Abstract Antibody‐drug conjugates are a cutting‐edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases.
Meng Li, Tiantian Wang, Dan Tan, Mengqi Wang, Changhai Lei, Yuqing Wang, Shi Hu   +6 more
wiley   +1 more source

Harnessing the therapeutic potential of bacterial extracellular vesicles via functional peptides

Interdisciplinary Medicine, EarlyView.
Bacterial extracellular vesicles (BEVs) are increasingly exploited as therapeutic agents or delivery vehicles for disease treatment due to their intrinsic structure, delivery capacity, immunogenic property, facile production, and versatile modification.
Yejiao Shi, Zelin Zheng, Wen Wang, Honggang Hu   +3 more
wiley   +1 more source

Production of hydroxyectoine from biogas by an engineered strain of Methylomicrobium alcaliphilum using a novel Taylor‐flow bioreactor

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The production of compatible solutes, such as ectoine and hydroxyectoine, is of great interest due to their industrial and biotechnological applications. Methylomicrobium alcaliphilum was genetically engineered to replace a native gene with a heterologous one, aiming to enhance ectoine production.
Raquel Herrero‐Lobo, Nuria Fernández‐González, Eva Marcos, María Alejandra Martínez, Pedro García‐Encina, María del Rosario Rodero, Raúl Muñoz, Sergio Bordel   +7 more
wiley   +1 more source

Dual process for improved recovery of essential oil and pectin from citrus waste

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Citrus essential oils (EO), particularly orange essential oil (OEO) and pectin, are high‐value chemical products widely used across various industries, including pharmaceuticals, food and beverages, detergents, and cosmetics. These compounds are present in the residual by‐products generated by juice production industries, and their ...
Jorge Welti‐Chanes, Oscar Hernández‐Meléndez, Mariana Morales‐de la Peña, Eduardo Bárzana   +3 more
wiley   +1 more source

CRISPR/Cas9 Knockout of Shell Matrix Protein 1 in the Slipper‐Snail Crepidula atrasolea

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Methods for CRISPR/Cas9 shell matrix protein knockout in the snail, Crepidula atrasolea including optimizing RNP delivery and embryo husbandry, to the use of Sanger and MiSeq sequencing, and high‐content screening of embryos to characterize the loss of Shell Matrix Protein 1 (SMP1) during larval shell development.
Grant Batzel, Yiqun Wang, Antonia Bock, Elbereth Chen, Stephanie Neal, Rebecca N. Lopez‐Anido, Yoon Lee, Evan Tjeerdema, Emily Ignatoff, Tejasvi Patil, Gabriela Ramirez, Maryna P. Lesoway, Amro Hamdoun, Deirdre C. Lyons   +13 more
wiley   +1 more source

Oral Delivery of Ellagic Acid Encapsulated in Milk Exosomes: Sex‐Based Differences in Bioavailability, Urolithin Production, and Gut Microbiota Modulation

Molecular Nutrition &Food Research, EarlyView.
Sex‐dependent effects on plasma metabolome and gut microbiota were observed after oral administration of ellagic acid (EA) encapsulated in milk‐derived exosomes (EXO‐EA) versus non‐encapsulated EA (NEA) and non‐loaded EXOs. EXO‐EA impacted plasma metabolome, modulated gut microbiota, and increased urolithin A and SCFA production sex‐dependently ...
María Ángeles Ávila‐Gálvez, María Romo‐Vaquero, Carmen Mazarío‐Gárgoles, Joao Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, María Victoria Selma, Antonio González‐Sarrías, Juan Carlos Espín   +8 more
wiley   +1 more source

Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims We previously demonstrated that leucine supplementation significantly reduces histone deacetylase 4 (HDAC4) expression induced by hindlimb immobilization, thereby attenuating the increase in HDAC4 protein levels and nuclear accumulation.
Paula K. N. Alves, André Cruz, William J. Silva, Afonso M. Melazzo, Siegfried Labeit, Volker Adams, Anselmo S. Moriscot   +6 more
wiley   +1 more source

Efficient Synthesis of Steroidal Intermediates with a C17 Side Chain from Phytosterols by Genetically Modified Mycolicibacterium neoaurum NRRL B‐3805 Strain

ChemistryOpen, EarlyView.
Two genetically modified strains are designed and constructed to produce 22‐hydroxy‐23,24‐bisnorchol‐4‐ene‐3‐one (4‐HBC) and 3‐oxo‐4,17‐pregnadiene‐20‐carboxylic acid methyl ester (PDCE) by disrupting and overexpressing the aldolase gene (thl) in the genetically modified strains of Mycolicibacterium neoaurum NRRL B‐3805, respectively, which are useful ...
Xuemei Li, Liangyan Zhu, Qiong Wu, Rui Zhang, Yiyin Liu, Na Liu, Jinhui Feng, Qiaqing Wu, Dunming Zhu   +8 more
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source