Results 131 to 140 of about 135,255 (300)
Exposure of cells with pulses of strong electric field can electroporate the cell plasma membrane, stimulate of excitable cells, or cause both effects. In some applications, e.g.
Saulė, Rita +2 more
core
Animal Research and One Health, EarlyView.vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul +6 more
wiley +1 more source
535 Electroporation of B cells is correlated with cell size change during B cell expansion
Journal for ImmunoTherapy of Cancer, 2020 Jian Chen, George Sun
doaj +1 more source
MicromachinesIn situ electroporation, a non-invasive technique for enhancing the permeability of cell membranes, has emerged as a powerful tool for intracellular delivery and manipulation. This method allows for the precise introduction of therapeutic agents, such as
Haizhen Sun +4 more
doaj +1 more source
A characterization of the reversibly electroporated penumbra during irreversible electroporation
Cancer Treatment and Research CommunicationsIrreversible electroporation (IRE) is a novel anticancer ablative treatment, which has been proposed to enhance the efficacy of chemotherapy in the periphery of the ablated area by capturing chemotherapy intracellularly. The aim of the current trial was to characterize the ablated lesion to get spatial information about the distribution of captured ...
Rasmus Virenfeldt Flak +5 more
openaire +3 more sources
In-situ Single Cell Electroporation Using Optoelectronic Tweezers
, 2008 Optoelectronic Tweezers are used to achieve light-induced, in-situ electroporation of HeLa cells. By controlling electrical bias, patterned light induces either single cell movement or electroporation.
Ming C. Wu +5 more
core +1 more source
Animal Research and One Health, EarlyView.The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang +4 more
wiley +1 more source
Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source