Results 241 to 250 of about 192,083 (323)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

open access: yesSmall, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa   +4 more
wiley   +1 more source

In situ monitoring of cell adhesion kinetics using label‐free optical biosensors: Evaluating anticancer potential and selectivity of natural compounds

open access: yesVIEW, EarlyView.
The limitations of conventional techniques hinder the identification of natural compounds with anticancer potential in terms of speed, throughput, sensitivity, and capability of continuous monitoring of relevant biological effects. Novel label‐free optical biosensors represent new opportunities in the discovery of drug candidates, eliminating these ...
Beatrix Péter   +10 more
wiley   +1 more source

Current and Emerging Energy Sources for Atrial Fibrillation Ablation: A Comparative Analysis of Clinical Efficacy, Safety, and Procedural Implementation. [PDF]

open access: yesJ Clin Med
Martignani C   +8 more
europepmc   +1 more source

Bordetella BcrH1 and BcrH2 Are Specific Chaperones for the Pore‐Forming Complex

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT Bordetella has a type III secretion system that secretes virulence proteins crucial to the establishment of infection. The genes encoding components of the Bordetella type III secretion system are located in the bsc region on the chromosome. This region includes the bcrH1 and bcrH2 genes, which respectively encode the proteins BcrH1 and BcrH2.
Yuya Kishino   +4 more
wiley   +1 more source

Convergence of mRNA technology and chimeric antigen receptor therapy: targeted technology optimizing targeted therapy. [PDF]

open access: yesJ Transl Med
Chen H   +10 more
europepmc   +1 more source

DsiRNA‐mediated silencing of Ceratitis capitata transformer or transformer‐2 leads to masculinization of XX embryos and systemic gene silencing in ovaries

open access: yesInsect Science, EarlyView.
We carried out functional studies using Dicer‐substrate small interfering RNAs (DsiRNAs), targeting the sex determination genes Cctransformer (Cctra) and Cctransformer‐2 (Cctra‐2) in the Mediterranean fruit fly (Ceratitis capitata). Microinjection of DsiRNAs into XX embryos (0‐1 h old) rapidly triggered the expression of male‐specific Cctra isoforms ...
Gennaro Volpe   +20 more
wiley   +1 more source

CRISPR/methotrexate-integrated strategy for TCR-T cell engineering with reduced chromosome 14 loss. [PDF]

open access: yesMol Ther Methods Clin Dev
Xu J   +18 more
europepmc   +1 more source

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