Results 41 to 50 of about 68,565 (138)

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, EarlyView.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Design and Construction of a Programmable Electroporation system for Biological Applications

, 2007
Studies into electroporation have grown rapidly in biotechnology and medicine in recent years. This paper presents the design and construction of a low cost programmable electroporation system for biological applications. The system consists of a control
Beeby, Steve, Brown, Andrew, Chad, John, Harris, Nick, Rodamporn, Somphop   +4 more
core  

Reprogramming human T cell function and specificity with non-viral genome targeting. [PDF]

, 2018
Decades of work have aimed to genetically reprogram T cells for therapeutic purposes1,2 using recombinant viral vectors, which do not target transgenes to specific genomic sites3,4.
Alkorta-Aranburu, Gorka, Ashworth, Alan, Bacchetta, Rosa, Carmody, David, Carnevale, Julia, Chen, Jeff W, Cho, Min, Del Gaudio, Daniela, Esensten, Jonathan H, Ferris, Andrea L, Greeley, Siri Atma W, Gurumurthy, Channabasavaiah B, Haugwitz, Michael, Herold, Kevan C, Hiatt, Joseph, Hughes, Stephen H, Krystofinski, Paige, Kupfer, Gary M, Lee, Michael R, Leonetti, Manuel D, Li, Han, Li, P Jonathan, Mao, Ying, Marson, Alexander, Matsumoto, Hiroyuki, May, Andrew P, Meffre, Eric, Morell, Montse, Nguyen, David N, Pellerin, Laurence, Puig-Saus, Cristina, Putnam, Amy L, Quadros, Rolen M, Ribas, Antoni, Romberg, Neil, Roncarolo, Maria Grazia, Roth, Theodore L, Saco, Justin, Schickel, Jean-Nicolas, Schumann, Kathrin, Shifrut, Eric, Smith, Baz, Tobin, Victoria, Weissman, Jonathan S, Yu, Ruby   +44 more
core  

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Quantification of propidium iodide delivery with millisecond electric pulses: A model study [PDF]

, 2014
A model study of propidium iodide delivery with millisecond electric pulses is presented; this work is a companion of the experimental efforts by Sadik et al. [1].
Lin, Hao, Yu, Miao
core  

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

Advanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

A robust system for RNA interference in the chicken using a modified microRNA operon [PDF]

, 2006
RNA interference (RNAi) provides an effective method to silence gene expression and investigate gene function. However, RNAi tools for the chicken embryo have largely been adapted from vectors designed for mammalian cells.
Boardman, Boden, Bron, Brown, Brummelkamp, Campbell, Cheryll Tickle, Chesnutt, Dai, Dickins, Domitrovich, Elbashir, Elizabeth M. Manning, Elizabeth R. Farrell, Fiona K. Bangs, Friedman, Gareth R. Howell, Gregory, Helen M. Sang, Hillier, Homburger, Hu, Hubbard, Isaacs, Jarriault, Katahira, Kate G. Storey, Kim, Kudo, Kyoji Ohyama, Lee, Lewis, Manche, Marysia Placzek, Melanie A. Sacco, Michael J. McGrew, Minks, Nick J. Van Hateren, Ohyama, Paddison, Paddison, Pam A. Halley, Pekarik, Raman M. Das, Silva, Simmen, Siolas, Stark, Stuart A. Wilson, Venugopal K. Nair, Victoria C. Porteous, Williams, Zeng, Zeng   +53 more
core   +1 more source

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

Advanced Science, EarlyView.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu, Weichen Xu, Xuexia Shan, Liping Sun, Shuo Liu, Xixi Sun, Shaoyue Li, Xiaodong Hou, Xiaowan Bo, Chengzhong Peng, Bin Huang, Huixiong Xu, Wenwen Yue   +12 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

Advanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source